Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a group of chronic, non-specific intestinal inflammatory diseases. The treatment of IBD focuses on alleviating intestinal inflammation. However, traditional drug treatment methods are limited by the side effects of systemic therapy, poor targeting of oral administ...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1614939/full |
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| author | Juan He Hong Guo Min Zou |
| author_facet | Juan He Hong Guo Min Zou |
| author_sort | Juan He |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a group of chronic, non-specific intestinal inflammatory diseases. The treatment of IBD focuses on alleviating intestinal inflammation. However, traditional drug treatment methods are limited by the side effects of systemic therapy, poor targeting of oral administration, and low bioavailability at the site of inflammation. Fortunately, the application of nanomaterials in the intestine is expected to alleviate these problems. Nanomaterials have unique physicochemical properties and can be used for targeted drug delivery through the mucus layer. Moreover, they can also be engulfed by macrophages through endocytosis, thereby regulating the immune environment of the intestine and potentially altering drug properties. In addition, nanomaterials can be divided into organic nanomaterials and inorganic nanomaterials according to their properties. The functional groups in organic nanomaterials directly determine the characteristics and effects of these materials. Among them, aromatic rings enhance drug stability, improve drug solubility and targeting, and exert anti-inflammatory, antioxidant, and immunomodulatory effects, which are conducive to the innovation of IBD treatment. This paper focuses on the role of aromatic rings, briefly describes the current therapeutic status of organic nanomaterials in inflammatory bowel disease, and discusses the deficiencies of existing research as well as directions for future studies. This paper provides insights into understanding the influence of functional groups on nanomaterials. |
| format | Article |
| id | doaj-art-19dc6061ef894e59a7e5e2bd4fa6907f |
| institution | OA Journals |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-19dc6061ef894e59a7e5e2bd4fa6907f2025-08-20T02:21:34ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-06-011310.3389/fbioe.2025.16149391614939Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel diseaseJuan He0Hong Guo1Min Zou2Chongqing Medical University, Chongqing, ChinaChongqing Medical University, Chongqing, ChinaChongqing General Hospital, Chongqing, ChinaInflammatory bowel disease (IBD) is a group of chronic, non-specific intestinal inflammatory diseases. The treatment of IBD focuses on alleviating intestinal inflammation. However, traditional drug treatment methods are limited by the side effects of systemic therapy, poor targeting of oral administration, and low bioavailability at the site of inflammation. Fortunately, the application of nanomaterials in the intestine is expected to alleviate these problems. Nanomaterials have unique physicochemical properties and can be used for targeted drug delivery through the mucus layer. Moreover, they can also be engulfed by macrophages through endocytosis, thereby regulating the immune environment of the intestine and potentially altering drug properties. In addition, nanomaterials can be divided into organic nanomaterials and inorganic nanomaterials according to their properties. The functional groups in organic nanomaterials directly determine the characteristics and effects of these materials. Among them, aromatic rings enhance drug stability, improve drug solubility and targeting, and exert anti-inflammatory, antioxidant, and immunomodulatory effects, which are conducive to the innovation of IBD treatment. This paper focuses on the role of aromatic rings, briefly describes the current therapeutic status of organic nanomaterials in inflammatory bowel disease, and discusses the deficiencies of existing research as well as directions for future studies. This paper provides insights into understanding the influence of functional groups on nanomaterials.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1614939/fullIBDnanomaterialsaromatic functional groupsinflammatorytreatment |
| spellingShingle | Juan He Hong Guo Min Zou Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease Frontiers in Bioengineering and Biotechnology IBD nanomaterials aromatic functional groups inflammatory treatment |
| title | Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| title_full | Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| title_fullStr | Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| title_full_unstemmed | Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| title_short | Research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| title_sort | research advances in nanomaterials with aromatic functional groups for the treatment of inflammatory bowel disease |
| topic | IBD nanomaterials aromatic functional groups inflammatory treatment |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1614939/full |
| work_keys_str_mv | AT juanhe researchadvancesinnanomaterialswitharomaticfunctionalgroupsforthetreatmentofinflammatoryboweldisease AT hongguo researchadvancesinnanomaterialswitharomaticfunctionalgroupsforthetreatmentofinflammatoryboweldisease AT minzou researchadvancesinnanomaterialswitharomaticfunctionalgroupsforthetreatmentofinflammatoryboweldisease |