Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review
Introduction National Comprehensive Cancer Network has recommended cryoablation to replace the resection in the treatment of medically operable non-small cell lung cancer (NSCLC). Cryoablation also has been used for the advanced NSCLC in randomised controlled trials. However, they have not been syst...
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| Format: | Article |
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BMJ Publishing Group
2020-09-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/9/e033460.full |
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| author | Dan Wang Yu Chen Hua Duan Shu-Yue Zheng Chufan Luo Xueni Fang Haoyue Pang Man Wang Tian Zhou Quanwang Li Kaiwen Hu |
| author_facet | Dan Wang Yu Chen Hua Duan Shu-Yue Zheng Chufan Luo Xueni Fang Haoyue Pang Man Wang Tian Zhou Quanwang Li Kaiwen Hu |
| author_sort | Dan Wang |
| collection | DOAJ |
| description | Introduction National Comprehensive Cancer Network has recommended cryoablation to replace the resection in the treatment of medically operable non-small cell lung cancer (NSCLC). Cryoablation also has been used for the advanced NSCLC in randomised controlled trials. However, they have not been systematically reviewed. Here, we provide a protocol to evaluate the effectiveness and safety of cryoablation in the treatment of advanced NSCLC.Methods and analyses We will search PubMed, Embase, the Cochrane Library, Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database without language restrictions from inception until 1 February 2020. Trial registers (International Clinical Trials Registry platform, the US National Institutes of Health Ongoing Trials Register and the ISRCTN registry) and reference lists of retrieved articles will also be searched. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes and assess the methodological quality by the Cochrane risk of bias tool. The strength of evidences will be evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach. Review Manager V.5.3 software will be used for data analyses. Meta-analyses will be performed if the data are sufficiently homogeneous. The primary outcomes will be objective response rate and overall survival. The secondary outcomes will be adverse effects, health-related quality of life, changes of immune indicators and surrogate outcomes (disease control rate, progression-free survival and survival rate).Ethics and dissemination Ethics approval is not required, as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research.PROSPERO registration number CRD42019138660. |
| format | Article |
| id | doaj-art-19dc4232fd8242a6b28bc9ae8b0ac136 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-19dc4232fd8242a6b28bc9ae8b0ac1362025-01-08T21:25:14ZengBMJ Publishing GroupBMJ Open2044-60552020-09-0110910.1136/bmjopen-2019-033460Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic reviewDan Wang0Yu Chen1Hua Duan2Shu-Yue Zheng3Chufan Luo4Xueni Fang5Haoyue Pang6Man Wang7Tian Zhou8Quanwang Li9Kaiwen Hu101 Department of Pediatrics, The First Affiliated Hospital Medical University, Wenzhou, Zhejiang, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaOncology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaGraduate School, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Respiratory Medicine, Daping Hospital,Army Medical University, Chongqing, People`s Republic of ChinaOncology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaOncology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaOncology Department, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, ChinaIntroduction National Comprehensive Cancer Network has recommended cryoablation to replace the resection in the treatment of medically operable non-small cell lung cancer (NSCLC). Cryoablation also has been used for the advanced NSCLC in randomised controlled trials. However, they have not been systematically reviewed. Here, we provide a protocol to evaluate the effectiveness and safety of cryoablation in the treatment of advanced NSCLC.Methods and analyses We will search PubMed, Embase, the Cochrane Library, Chinese Biomedical Database, China National Knowledge Infrastructure, Wanfang Database and Chinese Scientific Journal Database without language restrictions from inception until 1 February 2020. Trial registers (International Clinical Trials Registry platform, the US National Institutes of Health Ongoing Trials Register and the ISRCTN registry) and reference lists of retrieved articles will also be searched. Two reviewers will independently extract data on participants, interventions, comparisons, outcomes and assess the methodological quality by the Cochrane risk of bias tool. The strength of evidences will be evaluated according to the Grading of Recommendations Assessment, Development and Evaluation approach. Review Manager V.5.3 software will be used for data analyses. Meta-analyses will be performed if the data are sufficiently homogeneous. The primary outcomes will be objective response rate and overall survival. The secondary outcomes will be adverse effects, health-related quality of life, changes of immune indicators and surrogate outcomes (disease control rate, progression-free survival and survival rate).Ethics and dissemination Ethics approval is not required, as this study will not involve patients. The results of this study will be submitted to a peer-reviewed journal for publication, to inform both clinical practice and further research.PROSPERO registration number CRD42019138660.https://bmjopen.bmj.com/content/10/9/e033460.full |
| spellingShingle | Dan Wang Yu Chen Hua Duan Shu-Yue Zheng Chufan Luo Xueni Fang Haoyue Pang Man Wang Tian Zhou Quanwang Li Kaiwen Hu Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review BMJ Open |
| title | Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review |
| title_full | Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review |
| title_fullStr | Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review |
| title_full_unstemmed | Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review |
| title_short | Cryoablation for advanced non-small cell lung cancer: a protocol for a systematic review |
| title_sort | cryoablation for advanced non small cell lung cancer a protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/10/9/e033460.full |
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