Biomarkers of Inflammation in Obesity-Psoriatic Patients
Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, t...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2019/7353420 |
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| author | Carmen Rodríguez-Cerdeira Mónica Cordeiro-Rodríguez Miguel Carnero-Gregorio Adriana López-Barcenas Erick Martínez-Herrera Gabriella Fabbrocini Ardiana Sinani Roberto Arenas-Guzmán José Luís González-Cespón |
| author_facet | Carmen Rodríguez-Cerdeira Mónica Cordeiro-Rodríguez Miguel Carnero-Gregorio Adriana López-Barcenas Erick Martínez-Herrera Gabriella Fabbrocini Ardiana Sinani Roberto Arenas-Guzmán José Luís González-Cespón |
| author_sort | Carmen Rodríguez-Cerdeira |
| collection | DOAJ |
| description | Psoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psoriasis seems to be related to the severity of obesity. Patients with higher levels of obesity show poorer response to systemic treatments of psoriasis. Several studies have demonstrated that white adipose tissue is a crucial site of the formation of proinflammatory adipokines such as leptin, adiponectin, and resistin and classical cytokines such as interleukin- (IL-) 6 and tumour necrosis factor-α. In psoriasis, due to the proliferation of Th1, Th17, and Th22 cells, IL-22, among others, is produced in addition to the abovementioned cytokines. With respect to leptin and resistin, both of these adipokines are present in high levels in obese persons with psoriasis. Further, the plasma levels of leptin and resistin are related to the severity of psoriasis. These results strongly suggest that obesity, through proinflammatory pathways, is a predisposing factor to the development of psoriasis and that obesity aggravates existing psoriasis. Different inflammatory biomarkers link psoriasis and obesity. In this paper, the most important ones are described. |
| format | Article |
| id | doaj-art-19d92e2f9e6b42a7a73574daae0fdb90 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-19d92e2f9e6b42a7a73574daae0fdb902025-08-20T02:02:08ZengWileyMediators of Inflammation0962-93511466-18612019-01-01201910.1155/2019/73534207353420Biomarkers of Inflammation in Obesity-Psoriatic PatientsCarmen Rodríguez-Cerdeira0Mónica Cordeiro-Rodríguez1Miguel Carnero-Gregorio2Adriana López-Barcenas3Erick Martínez-Herrera4Gabriella Fabbrocini5Ardiana Sinani6Roberto Arenas-Guzmán7José Luís González-Cespón8Efficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, SpainEuropean Women Dermatological and Venereological Society (EWDVS), Vigo, SpainPsychodermatology Task Force of the Ibero Latin American College of Dermatology, ArgentinaEuropean Women Dermatological and Venereological Society (EWDVS), Vigo, SpainEuropean Women Dermatological and Venereological Society (EWDVS), Vigo, SpainEuropean Women Dermatological and Venereological Society (EWDVS), Vigo, SpainEfficiency, Quality and Costs in Health Services Research Group (EFISALUD), Health Research Institute, SERGAS-UVIGO, Vigo, SpainPsoriasis is a common chronic inflammatory multisystemic disease with a complex pathogenesis consisting of genetic, immunological, and environmental components. It is associated with a number of comorbidities, including diabetes, metabolic syndrome, obesity, and myocardial infarction. In addition, the severity of psoriasis seems to be related to the severity of obesity. Patients with higher levels of obesity show poorer response to systemic treatments of psoriasis. Several studies have demonstrated that white adipose tissue is a crucial site of the formation of proinflammatory adipokines such as leptin, adiponectin, and resistin and classical cytokines such as interleukin- (IL-) 6 and tumour necrosis factor-α. In psoriasis, due to the proliferation of Th1, Th17, and Th22 cells, IL-22, among others, is produced in addition to the abovementioned cytokines. With respect to leptin and resistin, both of these adipokines are present in high levels in obese persons with psoriasis. Further, the plasma levels of leptin and resistin are related to the severity of psoriasis. These results strongly suggest that obesity, through proinflammatory pathways, is a predisposing factor to the development of psoriasis and that obesity aggravates existing psoriasis. Different inflammatory biomarkers link psoriasis and obesity. In this paper, the most important ones are described.http://dx.doi.org/10.1155/2019/7353420 |
| spellingShingle | Carmen Rodríguez-Cerdeira Mónica Cordeiro-Rodríguez Miguel Carnero-Gregorio Adriana López-Barcenas Erick Martínez-Herrera Gabriella Fabbrocini Ardiana Sinani Roberto Arenas-Guzmán José Luís González-Cespón Biomarkers of Inflammation in Obesity-Psoriatic Patients Mediators of Inflammation |
| title | Biomarkers of Inflammation in Obesity-Psoriatic Patients |
| title_full | Biomarkers of Inflammation in Obesity-Psoriatic Patients |
| title_fullStr | Biomarkers of Inflammation in Obesity-Psoriatic Patients |
| title_full_unstemmed | Biomarkers of Inflammation in Obesity-Psoriatic Patients |
| title_short | Biomarkers of Inflammation in Obesity-Psoriatic Patients |
| title_sort | biomarkers of inflammation in obesity psoriatic patients |
| url | http://dx.doi.org/10.1155/2019/7353420 |
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