Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

Summary: The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB. Unraveling how non-coding mutations create oncogenic enhancers is k...

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Main Authors: Joana R. Costa, Yang Li, Nurkaiyisah Zaal Anuar, David O’Connor, Sunniyat Rahman, Tanya Rapoz-D’Silva, Kent T.M. Fung, Rachael Pocock, Zhaodong Li, Stephen Henderson, Lingyi Wang, Mateja E. Krulik, Sara Hyseni, Nivedita Singh, George Morrow, Yanping Guo, Daisy O.F. Gresham, Javier Herrero, Richard G. Jenner, A. Thomas Look, Dennis Kappei, Marc R. Mansour
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004760
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