Evaluating the Effect of Co-Registered Diagnostic MR Images Based CT Simulation on Target Volume Delineation and Dose Distribution for Tomotherapy of Rectal Cancer
Background: Magnetic Resonance Imaging (MRI) has become a complementary imaging method for the treatment planning process due to the limitations of Computed Tomography (CT) imaging.Objective: This study aimed to assess the effect of co-registered MRI and CT (MRI/CT)-based target delineation on the d...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2025-06-01
|
| Series: | Journal of Biomedical Physics and Engineering |
| Subjects: | |
| Online Access: | https://jbpe.sums.ac.ir/article_49511_f277c232cfb84ba90bcb166c3b888e84.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Background: Magnetic Resonance Imaging (MRI) has become a complementary imaging method for the treatment planning process due to the limitations of Computed Tomography (CT) imaging.Objective: This study aimed to assess the effect of co-registered MRI and CT (MRI/CT)-based target delineation on the dose to the target, small bowel, bladder, and femoral heads during Helical Tomotherapy (HT).Material and Methods: In this cross-sectional prospective study, MRI in a prone position were obtained for 12 patients with rectal cancer at one-day intervals with simulation CT. Following the co-registration process with the deformable algorithm, target volumes are defined. Gross Tumor Volume (GTV), Clinical Target Volume (CTV), and Planning Target Volume (PTV) were delineated for each CT and MRI/CT.Results: GTV, CTV, and PTV mean values were significantly higher in the CT-based target delineation method than those in the MRI/CT-based method. In MRI/CT-based plans, the mean HI value was significantly lower, and the mean Conformity Index (CI) value was significantly higher than that in CT-based plans. In a small bowl, the most of dosimetric parameters (Dmax, Dmean, D50%, D50%, V40%, and V45%) were significantly higher for the CT-based plans. In the bladder, all dosimetric parameters, except V30%, were statistically higher in CT-based plans. Conclusion: Co-registered MRI/CT-based treatment planning can produce better dose coverage for the target and reduce the delivered dose to the Organs at Risk (OARs) when compared to CT-based planning. |
|---|---|
| ISSN: | 2251-7200 |