Creatinine and Cystatin C: A Measure of Renal Function in Men With Testosterone-Induced Muscle Hypertrophy
Creatinine (Cr) is often used as a standalone gold standard marker of kidney function. Cystatin C (Cys C) is a less physiologically labile marker of renal function, particularly in certain subgroups. Herein, we analyze trends in cystatin C as compared to creatinine in men on testosterone replacement...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2024-10-01
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| Series: | American Journal of Men's Health |
| Online Access: | https://doi.org/10.1177/15579883241286654 |
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| Summary: | Creatinine (Cr) is often used as a standalone gold standard marker of kidney function. Cystatin C (Cys C) is a less physiologically labile marker of renal function, particularly in certain subgroups. Herein, we analyze trends in cystatin C as compared to creatinine in men on testosterone replacement therapy with varying body mass indices and percent body fat (PBF). This retrospective analysis observes 227 men with testosterone-induced muscle hypertrophy who visited a men’s health tertiary care clinic. All participants were characterized as competitive or recreational athletes. In patients with a normal body mass index (BMI), there was no clinically significant correlation between Cr and Cys C. Slight correlation was seen with overweight ( R 2 = .27) patients ( p < .0001) and obese ( R 2 = .29) patients ( p < .0001). Patients with PBF of 0%–10% ( n = 22) exhibited minimal ( R 2 = .23) positive correlation between Cys C and Cr ( p = .03). Positive correlation between Cys C and Cr in patients with PBF of 10%–20% was clinically negligible ( R 2 = .17, n = 87), modest ( R 2 = .49) in patients with PBF of 20%–30% ( n = 42), and evident ( R 2 = 1.00) in patients >30% ( n = 3) ( p < .0001, respectively). Cystatin C measurements display less variance compared with creatinine at differing BMI distinctions. At the upper limit of BMI or PBF in our patient population, cystatin C exhibits minimal to moderate variability compared with creatinine. |
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| ISSN: | 1557-9891 |