Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration
Abstract Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase in the aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based cartilage tissue engineering has emerged as a promising th...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BioMedical Engineering OnLine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12938-025-01342-3 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861701322211328 |
|---|---|
| author | Chun-Sheng Li Yan Xu Juan Li Shu-Hao Qin Shao-Wen Huang Xue-Mei Chen Yi Luo Cheng-Tao Gao Jian-Hui Xiao |
| author_facet | Chun-Sheng Li Yan Xu Juan Li Shu-Hao Qin Shao-Wen Huang Xue-Mei Chen Yi Luo Cheng-Tao Gao Jian-Hui Xiao |
| author_sort | Chun-Sheng Li |
| collection | DOAJ |
| description | Abstract Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase in the aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based cartilage tissue engineering has emerged as a promising therapeutic option for treating articular cartilage damage. Cellular scaffolds, which are among three key elements of tissue engineering, play significant roles in the repair of damaged articular cartilage by regulating cellular responses and promoting cartilage tissue regeneration. Biological macromolecules are commonly used as scaffold materials owing to their unique properties. For example, natural and synthetic polymer hydrogel scaffolds can effectively mimic the microenvironment of the natural extracellular matrix; exhibit high cytocompatibility, biocompatibility, and biodegradability; and have attracted increasing attention in bone and cartilage tissue engineering and regeneration medicine. Several types of hydrogel scaffolds have been fabricated to treat articular cartilage abnormalities. This article outlines the recent progress in the field of hydrogel scaffolds manufactured from various biomaterials for repairing damaged articular cartilage, discusses their advantages and disadvantages, and proposes directions for their future development. |
| format | Article |
| id | doaj-art-19c149d5c5154fcf9d1b1e1c23a3163b |
| institution | Kabale University |
| issn | 1475-925X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj-art-19c149d5c5154fcf9d1b1e1c23a3163b2025-02-09T12:47:31ZengBMCBioMedical Engineering OnLine1475-925X2025-02-0124112610.1186/s12938-025-01342-3Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regenerationChun-Sheng Li0Yan Xu1Juan Li2Shu-Hao Qin3Shao-Wen Huang4Xue-Mei Chen5Yi Luo6Cheng-Tao Gao7Jian-Hui Xiao8Institute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityInstitute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityNational Engineering Research Center for Compounding and Modification of Polymer Materials, Guizhou Material Industrial Technology Research InstituteInstitute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityNational Engineering Research Center for Compounding and Modification of Polymer Materials, Guizhou Material Industrial Technology Research InstituteInstitute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityInstitute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityNational Engineering Research Center for Compounding and Modification of Polymer Materials, Guizhou Material Industrial Technology Research InstituteInstitute of Medicinal Biotechnology, Affiliated Hospital of Zunyi Medical UniversityAbstract Articular cartilage injury is a serious bone disease that can result in disabilities. With the rapid increase in the aging population, this disorder has become an increasingly important public health issue. Recently, stem cell-based cartilage tissue engineering has emerged as a promising therapeutic option for treating articular cartilage damage. Cellular scaffolds, which are among three key elements of tissue engineering, play significant roles in the repair of damaged articular cartilage by regulating cellular responses and promoting cartilage tissue regeneration. Biological macromolecules are commonly used as scaffold materials owing to their unique properties. For example, natural and synthetic polymer hydrogel scaffolds can effectively mimic the microenvironment of the natural extracellular matrix; exhibit high cytocompatibility, biocompatibility, and biodegradability; and have attracted increasing attention in bone and cartilage tissue engineering and regeneration medicine. Several types of hydrogel scaffolds have been fabricated to treat articular cartilage abnormalities. This article outlines the recent progress in the field of hydrogel scaffolds manufactured from various biomaterials for repairing damaged articular cartilage, discusses their advantages and disadvantages, and proposes directions for their future development.https://doi.org/10.1186/s12938-025-01342-3Articular cartilage injuryCartilage tissue engineeringHydrogel scaffoldRepair and regeneration |
| spellingShingle | Chun-Sheng Li Yan Xu Juan Li Shu-Hao Qin Shao-Wen Huang Xue-Mei Chen Yi Luo Cheng-Tao Gao Jian-Hui Xiao Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration BioMedical Engineering OnLine Articular cartilage injury Cartilage tissue engineering Hydrogel scaffold Repair and regeneration |
| title | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| title_full | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| title_fullStr | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| title_full_unstemmed | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| title_short | Ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| title_sort | ultramodern natural and synthetic polymer hydrogel scaffolds for articular cartilage repair and regeneration |
| topic | Articular cartilage injury Cartilage tissue engineering Hydrogel scaffold Repair and regeneration |
| url | https://doi.org/10.1186/s12938-025-01342-3 |
| work_keys_str_mv | AT chunshengli ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT yanxu ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT juanli ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT shuhaoqin ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT shaowenhuang ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT xuemeichen ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT yiluo ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT chengtaogao ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration AT jianhuixiao ultramodernnaturalandsyntheticpolymerhydrogelscaffoldsforarticularcartilagerepairandregeneration |