Antitumor efficacy of biosynthesized manganese nanoparticles
This study aimed to evaluate the in vitro and in vivo antitumor potential of manganese nanoparticles, in management of hepatocellular carcinoma (HCC) induced in rats. Manganese nanoparticles were biosynthesized using Lactobacillus helveticus cells. In vitro study of manganese nanoparticles on HepG...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
ResearchersLinks, Ltd
2019-06-01
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| Series: | Novel Research in Microbiology Journal |
| Subjects: | |
| Online Access: | https://nrmj.journals.ekb.eg/article_37212_8ca3688f6fd547f6b4e300e2e449e245.pdf |
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| Summary: | This study aimed to evaluate the in vitro and in vivo antitumor potential of manganese nanoparticles, in
management of hepatocellular carcinoma (HCC) induced in rats. Manganese nanoparticles were biosynthesized
using Lactobacillus helveticus cells. In vitro study of manganese nanoparticles on HepG-2 (human cell line of a
well-differentiated HCC) revealed an IC50 of 21.5 mM. The in vivo efficacy of manganese nanoparticles was
evaluated by measuring the antioxidant activities against oxidative stress caused by diethylnitrosamine (DEN) in
rates liver tissues. This treatment significantly improved the alanine aminotransferase (ALT) activity and total
protein compared to DEN group. Results showed that manganese nanoparticles were effective in treatment of
HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles can serve as a good therapeutic
agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future. |
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| ISSN: | 2537-0286 2537-0294 |