Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets
A total of 40 piglets weaned at 21 d of age were used to study the effects of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets. Four piglets were randomly selected and killed before weaning, and the rest were randomly divided into two groups of three repli...
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Zhejiang University Press
2009-03-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
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| Online Access: | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.014 |
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| author | XU Yong LIU Hai-ping HU Cai-hong |
| author_facet | XU Yong LIU Hai-ping HU Cai-hong |
| author_sort | XU Yong |
| collection | DOAJ |
| description | A total of 40 piglets weaned at 21 d of age were used to study the effects of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets. Four piglets were randomly selected and killed before weaning, and the rest were randomly divided into two groups of three replicates each (six piglets per replicate) on the basis of initial body weight and sex, which were fed basal diet (control) and basal diet+3000 mg·kg<sup>-1</sup> Zn (as ZnO). Piglets were selected randomly to slaughter and oral administration of mixture with lactulose and mannitol, then their urine was collected after six hours. The changes of intestinal morphology were determined at d 21, 24, 28 and 35 of age. At the same time, plasma D-lactate level, diamine oxidase (DAO) activity and urine lactulose to mannitol ratio were measured to evaluate the intestinal permeability. The results show that the intestinal lesion of piglets was obvious in early weanling piglets, with crypt depth increasing by 13.93%(P<0.05) and villus height/crypt depth decreasing by 20.53%(P<0.05) at 28 d of age; plasma D-lactate level. DAO activity and urine lactulose to mannitol ratio increased significantly at 24 d of age, and remained high level to 35 d of age. However, supplementation with high level of zinc oxide alleviated stress and decreased intestinal permeability with reducing plasma D-lactate level, DAO activity and urine lactulose to mannitol ratio caused by early weanling of piglets. It is suggested that the addition of high level of zinc oxide relieved lesion of intestinal morphology and permeability of early weanling piglets so that to maintain the better intestinal barrier function. |
| format | Article |
| id | doaj-art-19bc8ec609434cafab6d4b6e39aeeb70 |
| institution | DOAJ |
| issn | 1008-9209 2097-5155 |
| language | English |
| publishDate | 2009-03-01 |
| publisher | Zhejiang University Press |
| record_format | Article |
| series | 浙江大学学报. 农业与生命科学版 |
| spelling | doaj-art-19bc8ec609434cafab6d4b6e39aeeb702025-08-20T03:16:06ZengZhejiang University Press浙江大学学报. 农业与生命科学版1008-92092097-51552009-03-013520921410.3785/j.issn.1008-9209.2009.02.01410089209Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling pigletsXU YongLIU Hai-pingHU Cai-hongA total of 40 piglets weaned at 21 d of age were used to study the effects of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets. Four piglets were randomly selected and killed before weaning, and the rest were randomly divided into two groups of three replicates each (six piglets per replicate) on the basis of initial body weight and sex, which were fed basal diet (control) and basal diet+3000 mg·kg<sup>-1</sup> Zn (as ZnO). Piglets were selected randomly to slaughter and oral administration of mixture with lactulose and mannitol, then their urine was collected after six hours. The changes of intestinal morphology were determined at d 21, 24, 28 and 35 of age. At the same time, plasma D-lactate level, diamine oxidase (DAO) activity and urine lactulose to mannitol ratio were measured to evaluate the intestinal permeability. The results show that the intestinal lesion of piglets was obvious in early weanling piglets, with crypt depth increasing by 13.93%(P<0.05) and villus height/crypt depth decreasing by 20.53%(P<0.05) at 28 d of age; plasma D-lactate level. DAO activity and urine lactulose to mannitol ratio increased significantly at 24 d of age, and remained high level to 35 d of age. However, supplementation with high level of zinc oxide alleviated stress and decreased intestinal permeability with reducing plasma D-lactate level, DAO activity and urine lactulose to mannitol ratio caused by early weanling of piglets. It is suggested that the addition of high level of zinc oxide relieved lesion of intestinal morphology and permeability of early weanling piglets so that to maintain the better intestinal barrier function.https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.014high level of zinc oxideearly weanlingpigletsintestinal morphologyintestinal permeability |
| spellingShingle | XU Yong LIU Hai-ping HU Cai-hong Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets 浙江大学学报. 农业与生命科学版 high level of zinc oxide early weanling piglets intestinal morphology intestinal permeability |
| title | Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| title_full | Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| title_fullStr | Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| title_full_unstemmed | Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| title_short | Effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| title_sort | effect of high level of zinc oxide on intestinal morphology and permeability in early weanling piglets |
| topic | high level of zinc oxide early weanling piglets intestinal morphology intestinal permeability |
| url | https://www.academax.com/doi/10.3785/j.issn.1008-9209.2009.02.014 |
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