Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

Endosomal sorting protein SNX4 limits synaptic vesicle docking and release

Sorting nexin 4 (SNX4) is an evolutionary conserved organizer of membrane recycling. In neurons, SNX4 accumulates in synapses, but how SNX4 affects synapse function remains unknown. We generated a conditional SNX4 knock-out mouse model and report that SNX4 cKO synapses show enhanced neurotransmissio...

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Bibliographic Details
Main Authors: Josse Poppinga, Nolan J Barrett, L Niels Cornelisse, Matthijs Verhage, Jan RT van Weering
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
neurotranmission
vesicle recruitment
plasticity
recycling endosome
hippocampal neuron
Online Access:https://elifesciences.org/articles/97910
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