Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis
Although docetaxel (DTX) is a first-line chemotherapeutic agent for treating prostate cancer (PCa), its clinical effectiveness is hampered by patients developing resistance following long-term, high-dose use. Additionally, its low bioavailability and significant toxicity further restrict its therape...
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Elsevier
2025-05-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127525003739 |
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| author | Yanzhong Zhao Binlong Chen Zichang Lin Zhi Li Jialong Fan Yanyan Huang Hao Zhang Leye He Bin Liu |
| author_facet | Yanzhong Zhao Binlong Chen Zichang Lin Zhi Li Jialong Fan Yanyan Huang Hao Zhang Leye He Bin Liu |
| author_sort | Yanzhong Zhao |
| collection | DOAJ |
| description | Although docetaxel (DTX) is a first-line chemotherapeutic agent for treating prostate cancer (PCa), its clinical effectiveness is hampered by patients developing resistance following long-term, high-dose use. Additionally, its low bioavailability and significant toxicity further restrict its therapeutic potential. To address these issues, we developed hyaluronan (HA)-modified Prussian blue nanoparticles (PB NPs) that co-load DTX and chitosan-encased silver nanoparticles (Chi-Ag NPs), aimed at enhancing solubility, targeting capability, and therapeutic efficacy. In vitro assays demonstrated that HA-Ag-PB@DTX NPs could synergistically kill PC-3 cells by effectively targeting tumor cells and inducing cell apoptosis. In vivo studies showed that HA-Ag-PB@DTX NPs significantly inhibited tumor growth in heterotopic tumor-bearing mice through enhanced penetrability in tumor tissues and synergistic effects. Furthermore, these NPs markedly reduced the toxicity of DTX due to their controlled release and targeted delivery mechanisms. In conclusion, we have successfully developed novel nanocomplexes that improve the dosage of DTX and provide a synergistic approach for PCa therapy. |
| format | Article |
| id | doaj-art-19bb3441d51944a7a05ca73274ff0f40 |
| institution | OA Journals |
| issn | 0264-1275 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj-art-19bb3441d51944a7a05ca73274ff0f402025-08-20T02:17:33ZengElsevierMaterials & Design0264-12752025-05-0125311395310.1016/j.matdes.2025.113953Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosisYanzhong Zhao0Binlong Chen1Zichang Lin2Zhi Li3Jialong Fan4Yanyan Huang5Hao Zhang6Leye He7Bin Liu8Health Management Center, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, China; Corresponding authors.Health Management Center, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, China; Department of Urology, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaDepartment of Laboratory Medicine, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaCollege of Biology, Hunan University, Changsha 410082, ChinaHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaDepartment of Nephrology, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaDepartment of Urology, The Third Xiangya Hospital, Central South University, Changsha 410013 Hunan, ChinaCollege of Biology, Hunan University, Changsha 410082, China; Corresponding authors.Although docetaxel (DTX) is a first-line chemotherapeutic agent for treating prostate cancer (PCa), its clinical effectiveness is hampered by patients developing resistance following long-term, high-dose use. Additionally, its low bioavailability and significant toxicity further restrict its therapeutic potential. To address these issues, we developed hyaluronan (HA)-modified Prussian blue nanoparticles (PB NPs) that co-load DTX and chitosan-encased silver nanoparticles (Chi-Ag NPs), aimed at enhancing solubility, targeting capability, and therapeutic efficacy. In vitro assays demonstrated that HA-Ag-PB@DTX NPs could synergistically kill PC-3 cells by effectively targeting tumor cells and inducing cell apoptosis. In vivo studies showed that HA-Ag-PB@DTX NPs significantly inhibited tumor growth in heterotopic tumor-bearing mice through enhanced penetrability in tumor tissues and synergistic effects. Furthermore, these NPs markedly reduced the toxicity of DTX due to their controlled release and targeted delivery mechanisms. In conclusion, we have successfully developed novel nanocomplexes that improve the dosage of DTX and provide a synergistic approach for PCa therapy.http://www.sciencedirect.com/science/article/pii/S0264127525003739Prostate cancerDocetaxelChi-Ag NPsSynergistic therapyDrug delivery |
| spellingShingle | Yanzhong Zhao Binlong Chen Zichang Lin Zhi Li Jialong Fan Yanyan Huang Hao Zhang Leye He Bin Liu Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis Materials & Design Prostate cancer Docetaxel Chi-Ag NPs Synergistic therapy Drug delivery |
| title | Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| title_full | Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| title_fullStr | Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| title_full_unstemmed | Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| title_short | Docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| title_sort | docetaxel combined with silver nanoparticles for synergistic therapy of prostate cancer via effectively inhibiting cell proliferation and inducing apoptosis |
| topic | Prostate cancer Docetaxel Chi-Ag NPs Synergistic therapy Drug delivery |
| url | http://www.sciencedirect.com/science/article/pii/S0264127525003739 |
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