Antimicrobial susceptibility patterns of bacillus anthracis isolates obtained from different origins
In this retrospective study, it was evaluated the antimicrobial susceptibility profiles of Bacillus anthracis isolates obtained from human, various samples (blood, spleen, lung, liver, meat) of dead animals (cattle, sheep, dog, horse) that died from anthrax and soil samples from the animal burial ar...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Kafkas University, Faculty of Veterinary Medicine
2024-12-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| Subjects: | |
| Online Access: | https://vetdergikafkas.org/pdf.php?id=3170 |
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| Summary: | In this retrospective study, it was evaluated the antimicrobial susceptibility profiles
of Bacillus anthracis isolates obtained from human, various samples (blood, spleen,
lung, liver, meat) of dead animals (cattle, sheep, dog, horse) that died from anthrax
and soil samples from the animal burial areas between 2012 and 2023 from Kars
province of Türkiye. In this context, a total of 87 B. anthracis isolates obtained from 1
human, two horses, 51 cattle, 7 sheep, 1 dog, and 25 soil were investigated. The isolates
were confirmed as B. anthracis using protective antigen (PA) and capsule (Cap) gen
specific PCRs. The Kirby-Bauer disk diffusion method was used for deternination
of antimicrobial susceptibility. Ten antimicrobials including penicillin, amoxicillin,
trimethoprim-sulfometoxazole, erythromycin, meropenem, streptomycin, ofloxacin,
ciprofloxacin, chloramphenicol, and clindamycin were tested. As a result of PCR, all
isolates were confirmed as fully virulent field strains of B. anthracis. All isolates were
found as susceptible to penicillin, amoxicillin, ofloxacin and ciprofloxacin. Since the
last studies in the region, a change in the antimicrobial profile of B. anthracis strains
was observed only for trimethoprim-sulfomethoxazole among the antimicrobials
tested, a transition from susceptibility to resistance. In conclusion, penicillin and
amoxicillin, are still the antibiotic of first choice for the prophylaxis and treatment
of anthrax. Ofloxacin and ciprofloxacin are also effective enough to be prescribed for
treatment. |
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| ISSN: | 1309-2251 |