Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease
It has been demonstrated that some viruses, such as the cytomegalovirus, code for G-protein coupled receptors not only to elude the immune system, but also to redirect cellular signaling in the receptor networks of the host cells. In view of the existence of receptor-receptor interactions, the hypot...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.166 |
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| author | Luigi F. Agnati Giuseppina Leo Susanna Genedani Diego Guidolin Nicola Andreoli Kjell Fuxe |
| author_facet | Luigi F. Agnati Giuseppina Leo Susanna Genedani Diego Guidolin Nicola Andreoli Kjell Fuxe |
| author_sort | Luigi F. Agnati |
| collection | DOAJ |
| description | It has been demonstrated that some viruses, such as the cytomegalovirus, code for G-protein coupled receptors not only to elude the immune system, but also to redirect cellular signaling in the receptor networks of the host cells. In view of the existence of receptor-receptor interactions, the hypothesis is introduced that these viral-coded receptors not only operate as constitutively active monomers, but also can affect other receptor function by interacting with receptors of the host cell. Furthermore, it is suggested that viruses could also insert not single receptors (monomers), but clusters of receptors (receptor mosaics), altering the cell metabolism in a profound way. The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease. |
| format | Article |
| id | doaj-art-19a9ecefe69a486a9b94855f227fcd90 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-19a9ecefe69a486a9b94855f227fcd902025-02-03T00:59:19ZengWileyThe Scientific World Journal1537-744X2007-01-0171073108110.1100/tsw.2007.166Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced DiseaseLuigi F. Agnati0Giuseppina Leo1Susanna Genedani2Diego Guidolin3Nicola Andreoli4Kjell Fuxe5Section of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, ItalySection of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, ItalySection of Pharmacology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, ItalySection of Anatomy, Department of Physiology and Human Anatomy, University of Padova, Padova, ItalySection of Physiology, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, ItalyDepartment of Neurosciences, Karolinska Institutet, Stockholm, SwedenIt has been demonstrated that some viruses, such as the cytomegalovirus, code for G-protein coupled receptors not only to elude the immune system, but also to redirect cellular signaling in the receptor networks of the host cells. In view of the existence of receptor-receptor interactions, the hypothesis is introduced that these viral-coded receptors not only operate as constitutively active monomers, but also can affect other receptor function by interacting with receptors of the host cell. Furthermore, it is suggested that viruses could also insert not single receptors (monomers), but clusters of receptors (receptor mosaics), altering the cell metabolism in a profound way. The prevention of viral receptor-induced changes in host receptor networks may give rise to novel antiviral drugs that counteract viral-induced disease.http://dx.doi.org/10.1100/tsw.2007.166 |
| spellingShingle | Luigi F. Agnati Giuseppina Leo Susanna Genedani Diego Guidolin Nicola Andreoli Kjell Fuxe Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease The Scientific World Journal |
| title | Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease |
| title_full | Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease |
| title_fullStr | Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease |
| title_full_unstemmed | Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease |
| title_short | Possible Relevance of Receptor-Receptor Interactions between Viral- and Host-Coded Receptors for Viral-Induced Disease |
| title_sort | possible relevance of receptor receptor interactions between viral and host coded receptors for viral induced disease |
| url | http://dx.doi.org/10.1100/tsw.2007.166 |
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