Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke
Hemorrhagic transformation (HT) is one of the severe complications of ischemic stroke,which may occur either during the natural course or as a consequence of treatments such as thrombolysisand thrombectomy. HT is associated with poor prognosis after ischemic stroke and influences clinicaltreatment d...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2025-05-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
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| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/3026 |
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| author | HUANG Yun⁃xiu WANG Ya⁃nan LIU Dong WU Bo LIU Jun⁃feng |
| author_facet | HUANG Yun⁃xiu WANG Ya⁃nan LIU Dong WU Bo LIU Jun⁃feng |
| author_sort | HUANG Yun⁃xiu |
| collection | DOAJ |
| description | Hemorrhagic transformation (HT) is one of the severe complications of ischemic stroke,which may occur either during the natural course or as a consequence of treatments such as thrombolysisand thrombectomy. HT is associated with poor prognosis after ischemic stroke and influences clinicaltreatment decisions. Disruption of blood⁃brain barrier (BBB) has been demonstrated as the main mechanismunderlying HT. Inflammatory responses contribute to this process by activating endothelial cells, recruitingimmune cells such as neutrophils and macrophages, and releasing inflammatory mediators includingproteases and reactive oxygen species, which further exacerbate vascular injury and BBB permeability,thereby promoting HT. Blood inflammatory markers may reflect these pathological processes and offervaluable biological information for early identification and risk stratification of HT. Classical inflammatorymarkers, such as matrix metalloproteinase⁃9 (MMP⁃9) and ferritin, have been demonstrated predictive valuefor HT. Recently increasing attention has been paid to investigate the mechanism and predictive potentialof novel markers, such as neutrophil gelatinase ⁃ associated lipocalin (NGAL), high ⁃ mobility group box 1(HMGB1) and nucleotide⁃binding oligomerization domain⁃like receptor protein 3 (NLRP3) inflammasome, forpredicting HT. This review focuses on the novel blood inflammatory markers and systematically describestheir correlation with HT, with the aim of providing a scientific basis for the mechanism investigation,accurate prediction and individualized therapeutic strategies of HT. |
| format | Article |
| id | doaj-art-19a4a9e3ba17495c8ae1facfa145ba99 |
| institution | OA Journals |
| issn | 1672-6731 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj-art-19a4a9e3ba17495c8ae1facfa145ba992025-08-20T02:33:00ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312025-05-0125536737410.3969/j.issn.1672⁃6731.2025.05.002Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic strokeHUANG Yun⁃xiu0WANG Ya⁃nan1 LIU Dong2WU Bo3LIU Jun⁃feng4Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaCenter of Cerebrovascular Diseases, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, The Second People's Hospital of Deyang, Deyang 618000, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaHemorrhagic transformation (HT) is one of the severe complications of ischemic stroke,which may occur either during the natural course or as a consequence of treatments such as thrombolysisand thrombectomy. HT is associated with poor prognosis after ischemic stroke and influences clinicaltreatment decisions. Disruption of blood⁃brain barrier (BBB) has been demonstrated as the main mechanismunderlying HT. Inflammatory responses contribute to this process by activating endothelial cells, recruitingimmune cells such as neutrophils and macrophages, and releasing inflammatory mediators includingproteases and reactive oxygen species, which further exacerbate vascular injury and BBB permeability,thereby promoting HT. Blood inflammatory markers may reflect these pathological processes and offervaluable biological information for early identification and risk stratification of HT. Classical inflammatorymarkers, such as matrix metalloproteinase⁃9 (MMP⁃9) and ferritin, have been demonstrated predictive valuefor HT. Recently increasing attention has been paid to investigate the mechanism and predictive potentialof novel markers, such as neutrophil gelatinase ⁃ associated lipocalin (NGAL), high ⁃ mobility group box 1(HMGB1) and nucleotide⁃binding oligomerization domain⁃like receptor protein 3 (NLRP3) inflammasome, forpredicting HT. This review focuses on the novel blood inflammatory markers and systematically describestheir correlation with HT, with the aim of providing a scientific basis for the mechanism investigation,accurate prediction and individualized therapeutic strategies of HT.http://www.cjcnn.org/index.php/cjcnn/article/view/3026ischemic strokecerebral hemorrhageinflammationbiomarkersbloodreview |
| spellingShingle | HUANG Yun⁃xiu WANG Ya⁃nan LIU Dong WU Bo LIU Jun⁃feng Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke Chinese Journal of Contemporary Neurology and Neurosurgery ischemic stroke cerebral hemorrhage inflammation biomarkers blood review |
| title | Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| title_full | Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| title_fullStr | Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| title_full_unstemmed | Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| title_short | Research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| title_sort | research progress on the relationship between novel blood inflammatory markers and hemorrhagic transformation after ischemic stroke |
| topic | ischemic stroke cerebral hemorrhage inflammation biomarkers blood review |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/3026 |
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