Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study
Objective: To assess reticulin fibrosis in benign hematologic disorders and to understand the impact of benign hematologic disorders on the immune system. Study Design: Cross-sectional study. Place and Duration of Study: The study was conducted at the Department of Hematology, Sheikh Zayed Hospital,...
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National University of Medical Sciences
2025-04-01
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| Online Access: | https://lifenscience.org/index.php/life-and-science/article/view/578 |
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| author | Yasir Shabbir Nazia Farooq Fahum Akhter Aetsam Ahmad Virk Muhammad Fayyaz Muhammad Eyyaz |
| author_facet | Yasir Shabbir Nazia Farooq Fahum Akhter Aetsam Ahmad Virk Muhammad Fayyaz Muhammad Eyyaz |
| author_sort | Yasir Shabbir |
| collection | DOAJ |
| description | Objective: To assess reticulin fibrosis in benign hematologic disorders and to understand the impact of benign
hematologic disorders on the immune system.
Study Design: Cross-sectional study.
Place and Duration of Study: The study was conducted at the Department of Hematology, Sheikh Zayed
Hospital, Lahore, Pakistan from January 2023 to June 2023.
Methods: Patients who had benign hematologic disorders, such as iron deficiency anemia, Megaloblastic
Anemia, Aplastic Anemia, and Immune Thrombocytopenic Purpura, were included in the research. Patients
with Malignant hematologic disorders and Individuals undergoing chemotherapy for any malignant disease
were excluded. There were 96 cases total in the sample, 24 for each illness. Following processing in the histology department, the data for reticulin fibers were analyzed using bone marrow samples from the anterior
iliac spine. An institutional ethics panel approved the research, and informed consent was acquired.
Results: The study found that the gender distribution of cases was significantly different among the four
groups. The average age of cases was not different among the four groups. Still, the Immune Thrombocytopenic Purpura group had the lowest average age of 40.5 years, and the Aplastic anemia group had the highest average age of 46.7 years. Among the hematological parameters, the hemoglobin level was the highest among the Immune Thrombocytopenic Purpura group, with an average of 10.8±1.9 g/dl. The median total leukocyte count for Iron Deficiency Anemia was 6.3, while the median total leukocyte count for megaloblastic anemia was 3.2, Aplastic Anemia was 1.8, and Immune Thrombocytopenic Purpura was 8.0. The median RDW count for Iron Deficiency Anemia was 42.0, Megaloblastic Anemia was 50.0, Aplastic Anemia was 48.5, and ITP was 48.0.
Conclusion: The study concluded that female gender, higher Hemoglobin level, higher MCH, Red blood cell
count, and lower platelet count may also help support the diagnosis of Immune Thrombocytopenic Purpura.
Identifying these parameters as diagnostic markers requires further research to confirm their status.
How to cite this: Shabbir Y, Farooq N, Akhter F, Virk AA, Fayyaz M, Eyyaz M. Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study. Life and Science. 2025; 6(2): 156-162. doi: http://doi.org/10.37185/LnS.1.1.578 |
| format | Article |
| id | doaj-art-199ea680e3f944faac6bd71de154f7f6 |
| institution | OA Journals |
| issn | 2521-0475 2708-2970 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | National University of Medical Sciences |
| record_format | Article |
| series | Life and Science |
| spelling | doaj-art-199ea680e3f944faac6bd71de154f7f62025-08-20T02:09:32ZengNational University of Medical SciencesLife and Science2521-04752708-29702025-04-0162070710.37185/LnS.1.1.578578Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional StudyYasir Shabbir0Nazia Farooq1Fahum Akhter2Aetsam Ahmad Virk3Muhammad Fayyaz4Muhammad Eyyaz5Gujranwala Medical College, Gujranwala, PakistanLahore Medical and Dental College, Lahore, PakistanLahore Medical and Dental College, Lahore, PakistanLahore Medical and Dental College, Lahore, PakistanUniversity of Gujrat, Gujrat, PakistanGujranwala Medical College, Gujranwala, PakistanObjective: To assess reticulin fibrosis in benign hematologic disorders and to understand the impact of benign hematologic disorders on the immune system. Study Design: Cross-sectional study. Place and Duration of Study: The study was conducted at the Department of Hematology, Sheikh Zayed Hospital, Lahore, Pakistan from January 2023 to June 2023. Methods: Patients who had benign hematologic disorders, such as iron deficiency anemia, Megaloblastic Anemia, Aplastic Anemia, and Immune Thrombocytopenic Purpura, were included in the research. Patients with Malignant hematologic disorders and Individuals undergoing chemotherapy for any malignant disease were excluded. There were 96 cases total in the sample, 24 for each illness. Following processing in the histology department, the data for reticulin fibers were analyzed using bone marrow samples from the anterior iliac spine. An institutional ethics panel approved the research, and informed consent was acquired. Results: The study found that the gender distribution of cases was significantly different among the four groups. The average age of cases was not different among the four groups. Still, the Immune Thrombocytopenic Purpura group had the lowest average age of 40.5 years, and the Aplastic anemia group had the highest average age of 46.7 years. Among the hematological parameters, the hemoglobin level was the highest among the Immune Thrombocytopenic Purpura group, with an average of 10.8±1.9 g/dl. The median total leukocyte count for Iron Deficiency Anemia was 6.3, while the median total leukocyte count for megaloblastic anemia was 3.2, Aplastic Anemia was 1.8, and Immune Thrombocytopenic Purpura was 8.0. The median RDW count for Iron Deficiency Anemia was 42.0, Megaloblastic Anemia was 50.0, Aplastic Anemia was 48.5, and ITP was 48.0. Conclusion: The study concluded that female gender, higher Hemoglobin level, higher MCH, Red blood cell count, and lower platelet count may also help support the diagnosis of Immune Thrombocytopenic Purpura. Identifying these parameters as diagnostic markers requires further research to confirm their status. How to cite this: Shabbir Y, Farooq N, Akhter F, Virk AA, Fayyaz M, Eyyaz M. Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study. Life and Science. 2025; 6(2): 156-162. doi: http://doi.org/10.37185/LnS.1.1.578https://lifenscience.org/index.php/life-and-science/article/view/578aplastic anemiahematologiciron deficiency anemiaimmune thrombocytopenic purpuramegaloblastic anemiareticulin fibrosis |
| spellingShingle | Yasir Shabbir Nazia Farooq Fahum Akhter Aetsam Ahmad Virk Muhammad Fayyaz Muhammad Eyyaz Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study Life and Science aplastic anemia hematologic iron deficiency anemia immune thrombocytopenic purpura megaloblastic anemia reticulin fibrosis |
| title | Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study |
| title_full | Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study |
| title_fullStr | Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study |
| title_full_unstemmed | Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study |
| title_short | Evaluation of Reticulin Fibrosis in Benign Hematologic Disorders in Lahore, Pakistan: A Cross-Sectional Study |
| title_sort | evaluation of reticulin fibrosis in benign hematologic disorders in lahore pakistan a cross sectional study |
| topic | aplastic anemia hematologic iron deficiency anemia immune thrombocytopenic purpura megaloblastic anemia reticulin fibrosis |
| url | https://lifenscience.org/index.php/life-and-science/article/view/578 |
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