Meningococcal vaccine 4CMenB elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection

Meningococcal vaccine 4CMenB elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection

ABSTRACT Retrospective epidemiological studies suggest that the licensed serogroup B meningococcal vaccine 4CMenB (Bexsero) provides some protection against the closely related pathogen Neisseria gonorrhoeae in humans. This result has been replicated in murine models of gonococcal colonization, with...

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Bibliographic Details
Main Authors: Joseph J. Zeppa, Jamie E. Fegan, Pauline Maiello, Epshita A. Islam, Isaac S. Lee, Christine Pham, Laura-Lee Caruso, Scott D. Gray-Owen
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
Neisseria gonorrhoeae
4CMenB
Bexsero
T-cell immunity
adaptive immunity
Online Access:https://journals.asm.org/doi/10.1128/msphere.00940-24
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