Intratumoral <i>Fusobacterium nucleatum</i> in Pancreatic Cancer: Current and Future Perspectives
The intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. <i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/14/1/2 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | The intratumoral microbiome plays a significant role in many cancers, such as lung, pancreatic, and colorectal cancer. Pancreatic cancer (PC) is one of the most lethal malignancies and is often diagnosed at advanced stages. <i>Fusobacterium nucleatum (Fn)</i>, an anaerobic Gram-negative bacterium primarily residing in the oral cavity, has garnered significant attention for its emerging role in several extra-oral human diseases and, lately, in pancreatic cancer progression and prognosis. It is now recognized as oncobacterium. <i>Fn</i> engages in pancreatic tumorigenesis and metastasis through multifaceted mechanisms, including immune response modulation, virulence factors, control of cell proliferation, intestinal metabolite interactions, DNA damage, and epithelial–mesenchymal transition. Additionally, compelling research suggests that <i>Fn</i> may exert detrimental effects on cancer treatment outcomes. This paper extends the perspective to pancreatic cancer associated with <i>Fn</i>. The central focus is to unravel the oncogenomic changes driven by <i>Fn in</i> colonization, initiation, and promotion of pancreatic cancer development. The presence of <i>Fusobacterium</i> species can be considered a prognostic marker of PC, and it is also correlated to chemoresistance. Furthermore, this review underscores the clinical research significance of <i>Fn</i> as a potential tumor biomarker and therapeutic target, offering a novel outlook on its applicability in cancer detection and prognostic assessment. It is thought that given the role of <i>Fn</i> in tumor formation and metastasis processes via its FadA, FapA, Fap2, and RadD, new therapies for tumor treatment targeting <i>Fn</i> will be developed. |
|---|---|
| ISSN: | 2076-0817 |