18F-Fluorodeoxyglucose Uptake in Cerebrospinal Fluid Reflects Both Brain Glucose Demand and Impaired Blood–Brain Barrier Transport in Alzheimer’s Disease

18F-Fluorodeoxyglucose Uptake in Cerebrospinal Fluid Reflects Both Brain Glucose Demand and Impaired Blood–Brain Barrier Transport in Alzheimer’s Disease

Glucose delivery to the brain requires transporters at the blood–brain barrier (BBB), whose downregulation may be associated with neuronal deficits in Alzheimer’s disease (AD). Whether this downregulation is due to reduced demand or primary BBB dysfunction remains unclear. We investigated novel 18F-...

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Bibliographic Details
Main Authors: Caterina Motta, Chiara Giuseppina Bonomi, Martina Poli, Nicola Biagio Mercuri, Alessandro Martorana, Agostino Chiaravalloti
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Applied Sciences
Subjects:
Alzheimer’s disease
glucose metabolism
FDG-PET
blood–brain barrier
APOE genotype
CSF
Online Access:https://www.mdpi.com/2076-3417/15/10/5677
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