Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study
Abstract Laryngeal squamous cell carcinoma (LSCC) presents significant treatment challenges, especially regarding recurrence after larynx-preservation therapy. We identified distinct microbial community structures between recurrence and non-recurrence groups, particularly highlighting the genera abu...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00789-5 |
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| author | Chi-Yao Hsueh Xiaohui Yuan Huiying Huang Yujie Shen Qiang Huang Weida Dong Danhui Li Hui-Ching Lau Xinhui Mao Simin Liang Lei Tao Ming Zhang Ji Sun Hongli Gong |
| author_facet | Chi-Yao Hsueh Xiaohui Yuan Huiying Huang Yujie Shen Qiang Huang Weida Dong Danhui Li Hui-Ching Lau Xinhui Mao Simin Liang Lei Tao Ming Zhang Ji Sun Hongli Gong |
| author_sort | Chi-Yao Hsueh |
| collection | DOAJ |
| description | Abstract Laryngeal squamous cell carcinoma (LSCC) presents significant treatment challenges, especially regarding recurrence after larynx-preservation therapy. We identified distinct microbial community structures between recurrence and non-recurrence groups, particularly highlighting the genera abundance of Fusobacterium and Serratia. However, larynx-preserving therapy did not significantly alter microbial diversity in recurrent patients. Survival analysis identified Fusobacterium and Serratia as independent prognostic factors for recurrence, leading to the development of a Serratia-Fusobacterium (SF) prognostic scoring model. The SF model achieved an AUC of 81.37% for predicting recurrence, outperforming the TNM staging system. LSCC patients classified as high-risk by the SF model exhibited significantly shorter disease-free survival (DFS) compared to low-risk patients in the LSCC cohort. Furthermore, the SF model demonstrated an AUC of 78.48% in the multi-center cohort for predicting recurrence. In conclusion, the Serratia-Fusobacterium prognostic scoring model can predict LSCC recurrence after larynx-preserving therapy and provide valuable insights to inform recommendations for LSCC surveillance. |
| format | Article |
| id | doaj-art-199817a8427341c4a60d0ec3d2ff3466 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-199817a8427341c4a60d0ec3d2ff34662025-08-20T03:42:40ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-08-0111111010.1038/s41522-025-00789-5Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control studyChi-Yao Hsueh0Xiaohui Yuan1Huiying Huang2Yujie Shen3Qiang Huang4Weida Dong5Danhui Li6Hui-Ching Lau7Xinhui Mao8Simin Liang9Lei Tao10Ming Zhang11Ji Sun12Hongli Gong13ENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityDepartment of Otorhinolaryngology, The First Affiliated Hospital of Nanjing Medical UniversityDepartment of Pathology, Renji Hospital, School of Medicine, Shanghai Jiao Tong UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityDepartment of Pathology, Eye & ENT Hospital, Fudan UniversityENT institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan UniversityAbstract Laryngeal squamous cell carcinoma (LSCC) presents significant treatment challenges, especially regarding recurrence after larynx-preservation therapy. We identified distinct microbial community structures between recurrence and non-recurrence groups, particularly highlighting the genera abundance of Fusobacterium and Serratia. However, larynx-preserving therapy did not significantly alter microbial diversity in recurrent patients. Survival analysis identified Fusobacterium and Serratia as independent prognostic factors for recurrence, leading to the development of a Serratia-Fusobacterium (SF) prognostic scoring model. The SF model achieved an AUC of 81.37% for predicting recurrence, outperforming the TNM staging system. LSCC patients classified as high-risk by the SF model exhibited significantly shorter disease-free survival (DFS) compared to low-risk patients in the LSCC cohort. Furthermore, the SF model demonstrated an AUC of 78.48% in the multi-center cohort for predicting recurrence. In conclusion, the Serratia-Fusobacterium prognostic scoring model can predict LSCC recurrence after larynx-preserving therapy and provide valuable insights to inform recommendations for LSCC surveillance.https://doi.org/10.1038/s41522-025-00789-5 |
| spellingShingle | Chi-Yao Hsueh Xiaohui Yuan Huiying Huang Yujie Shen Qiang Huang Weida Dong Danhui Li Hui-Ching Lau Xinhui Mao Simin Liang Lei Tao Ming Zhang Ji Sun Hongli Gong Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study npj Biofilms and Microbiomes |
| title | Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study |
| title_full | Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study |
| title_fullStr | Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study |
| title_full_unstemmed | Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study |
| title_short | Evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma: a multicenter case-control study |
| title_sort | evaluating the prognostic value of microbial communities in predicting recurrence of laryngeal carcinoma a multicenter case control study |
| url | https://doi.org/10.1038/s41522-025-00789-5 |
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