EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas.
Long non-coding RNAs are being increasingly recognised as important molecules involved in regulating a diverse array of biological functions. For example, many long non-coding RNAs have been associated with tumourigenesis and in this context their molecular functions often involves impacting on chro...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181902&type=printable |
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| author | Karol Nowicki-Osuch Yaoyong Li Mairi Challinor David T Gerrard Neil A Hanley Andrew D Sharrocks |
| author_facet | Karol Nowicki-Osuch Yaoyong Li Mairi Challinor David T Gerrard Neil A Hanley Andrew D Sharrocks |
| author_sort | Karol Nowicki-Osuch |
| collection | DOAJ |
| description | Long non-coding RNAs are being increasingly recognised as important molecules involved in regulating a diverse array of biological functions. For example, many long non-coding RNAs have been associated with tumourigenesis and in this context their molecular functions often involves impacting on chromatin and transcriptional control processes. One important cellular control system that is often deregulated in cancer cells is the ERK MAP kinase pathway. Here we have investigated whether ERK pathway signaling in response to EGF stimulation, leads to changes in the production of long non-coding RNAs. We identify several different classes of EGF pathway-regulated lncRNAs. We focus on one of the inducible lincRNAs, EGF inducible long intergenic non-coding RNA 1 (EINCR1). EINCR1 is predominantly nuclear and shows delayed activation kinetics compared to other immediate-early EGF-inducible genes. In humans it is expressed in a tissue-specific manner and is mainly confined to the heart but it exhibits little evolutionary conservation. Importantly, in several cancers EINCR1 shows elevated expression levels which correlate with poor survival in lung adenocarcinoma patients. In the context of lung adenocarcinomas, EINCR1 expression is anti-correlated with the expression of several protein coding EGF-regulated genes. A potential functional connection is demonstrated as EINCR1 overexpression is shown to reduce the expression of EGF-regulated protein coding genes including FOS and FOSB. |
| format | Article |
| id | doaj-art-199465dfedf9481897183a0e3cc57b4a |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-199465dfedf9481897183a0e3cc57b4a2025-08-20T02:01:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018190210.1371/journal.pone.0181902EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas.Karol Nowicki-OsuchYaoyong LiMairi ChallinorDavid T GerrardNeil A HanleyAndrew D SharrocksLong non-coding RNAs are being increasingly recognised as important molecules involved in regulating a diverse array of biological functions. For example, many long non-coding RNAs have been associated with tumourigenesis and in this context their molecular functions often involves impacting on chromatin and transcriptional control processes. One important cellular control system that is often deregulated in cancer cells is the ERK MAP kinase pathway. Here we have investigated whether ERK pathway signaling in response to EGF stimulation, leads to changes in the production of long non-coding RNAs. We identify several different classes of EGF pathway-regulated lncRNAs. We focus on one of the inducible lincRNAs, EGF inducible long intergenic non-coding RNA 1 (EINCR1). EINCR1 is predominantly nuclear and shows delayed activation kinetics compared to other immediate-early EGF-inducible genes. In humans it is expressed in a tissue-specific manner and is mainly confined to the heart but it exhibits little evolutionary conservation. Importantly, in several cancers EINCR1 shows elevated expression levels which correlate with poor survival in lung adenocarcinoma patients. In the context of lung adenocarcinomas, EINCR1 expression is anti-correlated with the expression of several protein coding EGF-regulated genes. A potential functional connection is demonstrated as EINCR1 overexpression is shown to reduce the expression of EGF-regulated protein coding genes including FOS and FOSB.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181902&type=printable |
| spellingShingle | Karol Nowicki-Osuch Yaoyong Li Mairi Challinor David T Gerrard Neil A Hanley Andrew D Sharrocks EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. PLoS ONE |
| title | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
| title_full | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
| title_fullStr | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
| title_full_unstemmed | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
| title_short | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
| title_sort | eincr1 is an egf inducible lincrna overexpressed in lung adenocarcinomas |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0181902&type=printable |
| work_keys_str_mv | AT karolnowickiosuch eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas AT yaoyongli eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas AT mairichallinor eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas AT davidtgerrard eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas AT neilahanley eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas AT andrewdsharrocks eincr1isanegfinduciblelincrnaoverexpressedinlungadenocarcinomas |