MODERN VIEWS ON BILATERAL BREAST CANCER
Presented modern literature data on the features of the pathogenesis, course, clinical and morphological expression and tumor characteristics, parameters and nodal metastasis of hematogenous bilateral breast cancer. Highlight the results of domestic and foreign studies in recent years to determine t...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/235 |
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| author | Ye. A. Fesik N. V. Krakhmal M. V. Zavyalova V. M. Perelmuter Ye. M. Slonimskaya S. V. Vtorushin |
| author_facet | Ye. A. Fesik N. V. Krakhmal M. V. Zavyalova V. M. Perelmuter Ye. M. Slonimskaya S. V. Vtorushin |
| author_sort | Ye. A. Fesik |
| collection | DOAJ |
| description | Presented modern literature data on the features of the pathogenesis, course, clinical and morphological expression and tumor characteristics, parameters and nodal metastasis of hematogenous bilateral breast cancer. Highlight the results of domestic and foreign studies in recent years to determine the prognostic factors and recurrence of synchronous and metachronous bilateral breast cancer. It was revealed that the frequency of bilateral breast tumor lesions varies widely, ranging from 0.1 to 20%, with metachronous tumors recorded significantly higher (69.6% ) than the synchronous (22.7%). The probability of occurrence of metachronous breast cancer is higher in women with a family history, as well as if they have a gene mutation BRCA-1. Found that the most common histological type of breast tumor with bilateral lesions is invasive ductal. However, the incidence of invasive lobular cancer and non-invasive lobular cancer is slightly higher among synchronous bilateral cancer compared with unilateral disease. Studies have shown that in a double-sided synchronous breast cancer tumor, as a rule, has a lower degree of differentiation, and the higher the expression level of estrogen receptors and progesterone receptors. Relevance of the issue because the identification of patterns in the study of lymphatic and hematogenous features bilateral metastasis of mammary tumors provides a basis for speculation about the differences in the progression of neoplastic disease in these groups and is a cause for further detailed research in this area to identify and evaluate the prognosis and also the choice of tactics of such patients. |
| format | Article |
| id | doaj-art-1991a1c1938d486b99325fcf3980b2d7 |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2014-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-1991a1c1938d486b99325fcf3980b2d72025-08-20T03:21:42ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-10-0113516016810.20538/1682-0363-2014-5-160-168233MODERN VIEWS ON BILATERAL BREAST CANCERYe. A. Fesik0N. V. Krakhmal1M. V. Zavyalova2V. M. Perelmuter3Ye. M. Slonimskaya4S. V. Vtorushin5Siberian State Medical University; Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University, TomskSiberian State Medical University; Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University; Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University; Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskSiberian State Medical University; Cancer Research Institute, Siberian Branch of the Russian Academy of Medical Sciences, TomskPresented modern literature data on the features of the pathogenesis, course, clinical and morphological expression and tumor characteristics, parameters and nodal metastasis of hematogenous bilateral breast cancer. Highlight the results of domestic and foreign studies in recent years to determine the prognostic factors and recurrence of synchronous and metachronous bilateral breast cancer. It was revealed that the frequency of bilateral breast tumor lesions varies widely, ranging from 0.1 to 20%, with metachronous tumors recorded significantly higher (69.6% ) than the synchronous (22.7%). The probability of occurrence of metachronous breast cancer is higher in women with a family history, as well as if they have a gene mutation BRCA-1. Found that the most common histological type of breast tumor with bilateral lesions is invasive ductal. However, the incidence of invasive lobular cancer and non-invasive lobular cancer is slightly higher among synchronous bilateral cancer compared with unilateral disease. Studies have shown that in a double-sided synchronous breast cancer tumor, as a rule, has a lower degree of differentiation, and the higher the expression level of estrogen receptors and progesterone receptors. Relevance of the issue because the identification of patterns in the study of lymphatic and hematogenous features bilateral metastasis of mammary tumors provides a basis for speculation about the differences in the progression of neoplastic disease in these groups and is a cause for further detailed research in this area to identify and evaluate the prognosis and also the choice of tactics of such patients.https://bulletin.ssmu.ru/jour/article/view/235bilateral breast cancerespecially flowmorphologyprognosis |
| spellingShingle | Ye. A. Fesik N. V. Krakhmal M. V. Zavyalova V. M. Perelmuter Ye. M. Slonimskaya S. V. Vtorushin MODERN VIEWS ON BILATERAL BREAST CANCER Бюллетень сибирской медицины bilateral breast cancer especially flow morphology prognosis |
| title | MODERN VIEWS ON BILATERAL BREAST CANCER |
| title_full | MODERN VIEWS ON BILATERAL BREAST CANCER |
| title_fullStr | MODERN VIEWS ON BILATERAL BREAST CANCER |
| title_full_unstemmed | MODERN VIEWS ON BILATERAL BREAST CANCER |
| title_short | MODERN VIEWS ON BILATERAL BREAST CANCER |
| title_sort | modern views on bilateral breast cancer |
| topic | bilateral breast cancer especially flow morphology prognosis |
| url | https://bulletin.ssmu.ru/jour/article/view/235 |
| work_keys_str_mv | AT yeafesik modernviewsonbilateralbreastcancer AT nvkrakhmal modernviewsonbilateralbreastcancer AT mvzavyalova modernviewsonbilateralbreastcancer AT vmperelmuter modernviewsonbilateralbreastcancer AT yemslonimskaya modernviewsonbilateralbreastcancer AT svvtorushin modernviewsonbilateralbreastcancer |