PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration

PDE4B promotes JNK/NLRP3 activation in the nucleus pulposus and mediates intervertebral disc degeneration

Abstract Intervertebral disc degeneration disease (IDD) is one of the leading causes of disability, and current therapies are ineffective. Phosphodiesterase 4B (PDE4B) plays essential roles in regulating the activation of the NLRP3 inflammasome. However, whether PDE4B or NLRP3 is involved in the dev...

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Bibliographic Details
Main Authors: Weixing Xu, Rana Dhar, Kaiyue Li, Danyang Zheng, Minxin He, Weiguo Ding, Long Xin, Bin Xu, Yuqing He, Qi Peng, Huifang Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Intervertebral disc degeneration disease
Phosphodiesterase 4B
Nucleus pulposus
NLRP3
Online Access:https://doi.org/10.1038/s41598-025-88053-w
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