Lipoprotein(a) among normotensive patients and risk of incident hypertension
Abstract Lipoprotein(a) has been shown to be disruptive to local endothelial cells, whose integrity is critical to blood pressure (BP) regulation. Cross‐sectional analysis has shown an association between lipoprotein(a) and prevalent hypertension, though it is unclear if lipoprotein(a) increases ris...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | The Journal of Clinical Hypertension |
| Online Access: | https://doi.org/10.1111/jch.14904 |
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| author | Alexander R. Zheutlin Joshua A. Jacobs Brian Stamm Regina Royan |
| author_facet | Alexander R. Zheutlin Joshua A. Jacobs Brian Stamm Regina Royan |
| author_sort | Alexander R. Zheutlin |
| collection | DOAJ |
| description | Abstract Lipoprotein(a) has been shown to be disruptive to local endothelial cells, whose integrity is critical to blood pressure (BP) regulation. Cross‐sectional analysis has shown an association between lipoprotein(a) and prevalent hypertension, though it is unclear if lipoprotein(a) increases risk of incident hypertension. To assess this, the authors measured baseline lipoprotein(a) among 5307 normotensive patients (median age 26 years (interquartile range [IQR] 12–50) and used Cox proportional hazard models to generate hazard rations (HR) with 95% confidence intervals (CI; median follow‐up 10‐years). The authors categorized lipoprotein(a) as <15 mg/dL, 15–<30 mg/dL, 30–50 mg/dL, >50 mg/dL, and performed subgroup analysis of adults >50 years at baseline. Incident hypertension was defined as a measured BP ≥140/90 mm Hg or a new ICD‐9/10 code. After adjustment, hypertension for patients with baseline lipoprotein(a) 15–<30 mg/dL, 30–50 mg/dL, and >50 mg/dL was 0.91 (0.72–1.16), 1.05 (0.79–1.38), and 1.02 (0.83–1.26; vs. <15 mg/dL). However, among adults >50 years, lipoprotein(a) >50 mg/dL was associated with increased incident hypertension (1.62 [1.17–2.26]). |
| format | Article |
| id | doaj-art-19904da30075436da1c06b1d95fb3fb1 |
| institution | DOAJ |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-19904da30075436da1c06b1d95fb3fb12025-08-20T02:48:39ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-11-0126111313131710.1111/jch.14904Lipoprotein(a) among normotensive patients and risk of incident hypertensionAlexander R. Zheutlin0Joshua A. Jacobs1Brian Stamm2Regina Royan3Division of Cardiology Feinberg School of Medicine Northwestern University Chicago Illinois USAIntermountain Healthcare Department of Population Health Sciences Spencer Fox Eccles School of Medicine University of Utah Salt Lake City Utah USADepartment of Neurology and National Clinician Scholars Program University of Michigan Ann Arbor Michigan USADepartment of Emergency Medicine University of Michigan Ann Arbor Michigan USAAbstract Lipoprotein(a) has been shown to be disruptive to local endothelial cells, whose integrity is critical to blood pressure (BP) regulation. Cross‐sectional analysis has shown an association between lipoprotein(a) and prevalent hypertension, though it is unclear if lipoprotein(a) increases risk of incident hypertension. To assess this, the authors measured baseline lipoprotein(a) among 5307 normotensive patients (median age 26 years (interquartile range [IQR] 12–50) and used Cox proportional hazard models to generate hazard rations (HR) with 95% confidence intervals (CI; median follow‐up 10‐years). The authors categorized lipoprotein(a) as <15 mg/dL, 15–<30 mg/dL, 30–50 mg/dL, >50 mg/dL, and performed subgroup analysis of adults >50 years at baseline. Incident hypertension was defined as a measured BP ≥140/90 mm Hg or a new ICD‐9/10 code. After adjustment, hypertension for patients with baseline lipoprotein(a) 15–<30 mg/dL, 30–50 mg/dL, and >50 mg/dL was 0.91 (0.72–1.16), 1.05 (0.79–1.38), and 1.02 (0.83–1.26; vs. <15 mg/dL). However, among adults >50 years, lipoprotein(a) >50 mg/dL was associated with increased incident hypertension (1.62 [1.17–2.26]).https://doi.org/10.1111/jch.14904 |
| spellingShingle | Alexander R. Zheutlin Joshua A. Jacobs Brian Stamm Regina Royan Lipoprotein(a) among normotensive patients and risk of incident hypertension The Journal of Clinical Hypertension |
| title | Lipoprotein(a) among normotensive patients and risk of incident hypertension |
| title_full | Lipoprotein(a) among normotensive patients and risk of incident hypertension |
| title_fullStr | Lipoprotein(a) among normotensive patients and risk of incident hypertension |
| title_full_unstemmed | Lipoprotein(a) among normotensive patients and risk of incident hypertension |
| title_short | Lipoprotein(a) among normotensive patients and risk of incident hypertension |
| title_sort | lipoprotein a among normotensive patients and risk of incident hypertension |
| url | https://doi.org/10.1111/jch.14904 |
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