Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women

Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-bas...

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Main Authors: Lyla Blake-Gumbs, Zhengyi Chen, Cheryl L. Thompson, Nathan A. Berger, Thomas C. Tucker, Li Li
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Obesity
Online Access:http://dx.doi.org/10.1155/2012/857510
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author Lyla Blake-Gumbs
Zhengyi Chen
Cheryl L. Thompson
Nathan A. Berger
Thomas C. Tucker
Li Li
author_facet Lyla Blake-Gumbs
Zhengyi Chen
Cheryl L. Thompson
Nathan A. Berger
Thomas C. Tucker
Li Li
author_sort Lyla Blake-Gumbs
collection DOAJ
description Purpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2 change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.
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spelling doaj-art-1988a5c5a7f04909aeca2db3ecdaaedb2025-02-03T01:24:17ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/857510857510Adult BMI Change and Risk of Colon Cancer in Postmenopausal WomenLyla Blake-Gumbs0Zhengyi Chen1Cheryl L. Thompson2Nathan A. Berger3Thomas C. Tucker4Li Li5Department of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USADepartment of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USADepartment of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USACase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USAMarkey Cancer Center, University of Kentucky, Lexington, KY 40536, USADepartment of Family Medicine and Community Health, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-7136, USAPurpose. We recently reported an association of adult BMI change with colon cancer risk. Here, we sought to further explore this association with respect to postmenopausal HRT use in a larger study population. Methods. We included 1,457 postmenopausal women participating in an ongoing population-based case-control study of colon cancer. Results. We confirmed a previously reported association of adulthood weight gain and increased risk of colon cancer: compared to those with <5 kg/m2 change of BMI, women who reported moderate (5–10 kg/m2) and large (>10 kg/m2) BMI changes since their 20s had OR estimates of 1.54 (95% CI = 1.09–2.19) and 1.45 (95% CI = 0.90–2.33), respectively (P for trend = 0.05). Stratified analyses showed that this association was limited to HRT nonusers: ORs were 1.77 (95% CI = 1.02–3.05) and 2.21 (95% CI = 1.09–4.45), respectively (P for trend = 0.03), for BMI changes occurring between the 20s decade and time of recruitment among non-users. Similar associations were observed for BMI changes since the 30s decade. There was no association among HRT users. Conclusion. Our results suggest early adulthood weight gain increases colon cancer risk in postmenopausal women who do not use HRT.http://dx.doi.org/10.1155/2012/857510
spellingShingle Lyla Blake-Gumbs
Zhengyi Chen
Cheryl L. Thompson
Nathan A. Berger
Thomas C. Tucker
Li Li
Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
Journal of Obesity
title Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
title_full Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
title_fullStr Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
title_full_unstemmed Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
title_short Adult BMI Change and Risk of Colon Cancer in Postmenopausal Women
title_sort adult bmi change and risk of colon cancer in postmenopausal women
url http://dx.doi.org/10.1155/2012/857510
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AT cheryllthompson adultbmichangeandriskofcoloncancerinpostmenopausalwomen
AT nathanaberger adultbmichangeandriskofcoloncancerinpostmenopausalwomen
AT thomasctucker adultbmichangeandriskofcoloncancerinpostmenopausalwomen
AT lili adultbmichangeandriskofcoloncancerinpostmenopausalwomen