Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia
Gusti Fungani Harti,1 Syifa Nur Maulida,2 Evan Susandi,3 Trinugroho Heri Fadjari,1 Uun Sumardi,3 Bachti Alisjahbana,2,3 Indra Wijaya1 1Division of Hemato and Oncology Medic, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, Indones...
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Dove Medical Press
2025-02-01
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| Series: | Journal of Blood Medicine |
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| author | Harti GF Maulida SN Susandi E Fadjari TH Sumardi U Alisjahbana B Wijaya I |
| author_facet | Harti GF Maulida SN Susandi E Fadjari TH Sumardi U Alisjahbana B Wijaya I |
| author_sort | Harti GF |
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| description | Gusti Fungani Harti,1 Syifa Nur Maulida,2 Evan Susandi,3 Trinugroho Heri Fadjari,1 Uun Sumardi,3 Bachti Alisjahbana,2,3 Indra Wijaya1 1Division of Hemato and Oncology Medic, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia; 2Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia; 3Division of Tropical and Infectious Disease, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Indra Wijaya, Division of Hemato and Oncology Medic, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Pasteur No. 38, Bandung, West Java, 40161, Indonesia, Email indra.wijaya@unpad.ac.idPurpose: This study aimed to compare platelet count, platelet indices, lymphocyte, and systemic inflammation indices between surviving and non-surviving COVID-19 patients, measured at admission and on the eighth day of hospitalization.Patients and Methods: A retrospective cohort study was conducted on COVID-19 patients hospitalized at Hasan Sadikin General Hospital, Bandung, from March to December 2020. Patient characteristics and laboratory data were sourced from medical records and the Clinical Pathology Laboratory. Bivariate analysis was performed to determine the comparison of platelet indexes between Surviving and Non-Surviving COVID-19 patients depending on data distribution. Significantly correlated variables in Bivariate analysis were included in the ROC analysis, with the AUC used to identify optimal threshold values for laboratory parameters.Results: Data from 132 patients were analyzed, with 106 (80.3%) surviving and 32 (19.7%) not surviving. Non-surviving patients had lower platelet count, PLTCT, and lymphocyte levels but higher MPV and PDW compared to survivors. Receiver operating characteristic (ROC) analysis revealed that on day 1, lymphocytes had a higher area under the curve (AUC) than MPV. On day 8, lymphocytes had the highest AUC, followed by platelet count, MPV, PLTCT, and PDW.Conclusion: Platelet indices, lymphocyte counts, and systemic inflammation index have the potential to distinguish the severity of COVID-19.Keywords: mortality, platelet indices, thrombocytopenia, SII, NLR |
| format | Article |
| id | doaj-art-1986bbb557b1449cb1157c6c28058d21 |
| institution | Kabale University |
| issn | 1179-2736 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj-art-1986bbb557b1449cb1157c6c28058d212025-02-04T17:15:41ZengDove Medical PressJournal of Blood Medicine1179-27362025-02-01Volume 16617499843Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, IndonesiaHarti GFMaulida SNSusandi EFadjari THSumardi UAlisjahbana BWijaya IGusti Fungani Harti,1 Syifa Nur Maulida,2 Evan Susandi,3 Trinugroho Heri Fadjari,1 Uun Sumardi,3 Bachti Alisjahbana,2,3 Indra Wijaya1 1Division of Hemato and Oncology Medic, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia; 2Research Center for Care and Control of Infectious Disease, Universitas Padjadjaran, Bandung, Indonesia; 3Division of Tropical and Infectious Disease, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Bandung, IndonesiaCorrespondence: Indra Wijaya, Division of Hemato and Oncology Medic, Department of Internal Medicine, Hasan Sadikin General Hospital, Faculty of Medicine Universitas Padjadjaran, Pasteur No. 38, Bandung, West Java, 40161, Indonesia, Email indra.wijaya@unpad.ac.idPurpose: This study aimed to compare platelet count, platelet indices, lymphocyte, and systemic inflammation indices between surviving and non-surviving COVID-19 patients, measured at admission and on the eighth day of hospitalization.Patients and Methods: A retrospective cohort study was conducted on COVID-19 patients hospitalized at Hasan Sadikin General Hospital, Bandung, from March to December 2020. Patient characteristics and laboratory data were sourced from medical records and the Clinical Pathology Laboratory. Bivariate analysis was performed to determine the comparison of platelet indexes between Surviving and Non-Surviving COVID-19 patients depending on data distribution. Significantly correlated variables in Bivariate analysis were included in the ROC analysis, with the AUC used to identify optimal threshold values for laboratory parameters.Results: Data from 132 patients were analyzed, with 106 (80.3%) surviving and 32 (19.7%) not surviving. Non-surviving patients had lower platelet count, PLTCT, and lymphocyte levels but higher MPV and PDW compared to survivors. Receiver operating characteristic (ROC) analysis revealed that on day 1, lymphocytes had a higher area under the curve (AUC) than MPV. On day 8, lymphocytes had the highest AUC, followed by platelet count, MPV, PLTCT, and PDW.Conclusion: Platelet indices, lymphocyte counts, and systemic inflammation index have the potential to distinguish the severity of COVID-19.Keywords: mortality, platelet indices, thrombocytopenia, SII, NLRhttps://www.dovepress.com/comparison-of-platelet-indices-lymphocyte-and-systemic-inflammation-in-peer-reviewed-fulltext-article-JBMmortalityplatelet indicesthrombocytopeniasiinlr |
| spellingShingle | Harti GF Maulida SN Susandi E Fadjari TH Sumardi U Alisjahbana B Wijaya I Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia Journal of Blood Medicine mortality platelet indices thrombocytopenia sii nlr |
| title | Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia |
| title_full | Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia |
| title_fullStr | Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia |
| title_full_unstemmed | Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia |
| title_short | Comparison of Platelet Indices, Lymphocyte, and Systemic Inflammation Indices on Days 1 and 8 in Surviving and Non-Surviving COVID-19 Patients at Hasan Sadikin General Hospital, Bandung, Indonesia |
| title_sort | comparison of platelet indices lymphocyte and systemic inflammation indices on days 1 and 8 in surviving and non surviving covid 19 patients at hasan sadikin general hospital bandung indonesia |
| topic | mortality platelet indices thrombocytopenia sii nlr |
| url | https://www.dovepress.com/comparison-of-platelet-indices-lymphocyte-and-systemic-inflammation-in-peer-reviewed-fulltext-article-JBM |
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