Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy
Neuroplasticity is a common phenomenon in the human brain following nerve injury. It is defined as the brain’s ability to reorganize by creating new neural pathways in order to adapt to change. Here, we use task-related and resting-state fMRI to investigate neuroplasticity in the primary sensory (S1...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2017/8796239 |
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| _version_ | 1832554133037514752 |
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| author | Wenwen Song Minhui Dai Lihua Xuan Zhijian Cao Sisi Zhou Courtney Lang Kun Lv Maosheng Xu Jian Kong |
| author_facet | Wenwen Song Minhui Dai Lihua Xuan Zhijian Cao Sisi Zhou Courtney Lang Kun Lv Maosheng Xu Jian Kong |
| author_sort | Wenwen Song |
| collection | DOAJ |
| description | Neuroplasticity is a common phenomenon in the human brain following nerve injury. It is defined as the brain’s ability to reorganize by creating new neural pathways in order to adapt to change. Here, we use task-related and resting-state fMRI to investigate neuroplasticity in the primary sensory (S1) and motor cortex (M1) in patients with acute Bell’s palsy (BP). We found that the period directly following the onset of BP (less than 14 days) is associated with significant decreases in regional homogeneity (ReHo), fractional amplitude of low frequency fluctuations (fALFF), and intrinsic connectivity contrast (ICC) values in the contralateral S1/M1 and in ReHo and ICC values in the ipsilateral S1/M1, compared to healthy controls. The regions with decreased ReHo, fALFF, and ICC values were in both the face and hand region of S1/M1 as indicated by resting-state fMRI but not task-related fMRI. Our results suggest that the early stages of BP are associated with functional neuroplasticity in both the face and hand regions of S1/M1 and that resting-state functional fMRI may be a sensitive tool to detect these early stages of plasticity in patient populations. |
| format | Article |
| id | doaj-art-198079b0885649c094c6e59fdcf83657 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-198079b0885649c094c6e59fdcf836572025-02-03T05:52:16ZengWileyNeural Plasticity2090-59041687-54432017-01-01201710.1155/2017/87962398796239Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s PalsyWenwen Song0Minhui Dai1Lihua Xuan2Zhijian Cao3Sisi Zhou4Courtney Lang5Kun Lv6Maosheng Xu7Jian Kong8The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USAThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USANeuroplasticity is a common phenomenon in the human brain following nerve injury. It is defined as the brain’s ability to reorganize by creating new neural pathways in order to adapt to change. Here, we use task-related and resting-state fMRI to investigate neuroplasticity in the primary sensory (S1) and motor cortex (M1) in patients with acute Bell’s palsy (BP). We found that the period directly following the onset of BP (less than 14 days) is associated with significant decreases in regional homogeneity (ReHo), fractional amplitude of low frequency fluctuations (fALFF), and intrinsic connectivity contrast (ICC) values in the contralateral S1/M1 and in ReHo and ICC values in the ipsilateral S1/M1, compared to healthy controls. The regions with decreased ReHo, fALFF, and ICC values were in both the face and hand region of S1/M1 as indicated by resting-state fMRI but not task-related fMRI. Our results suggest that the early stages of BP are associated with functional neuroplasticity in both the face and hand regions of S1/M1 and that resting-state functional fMRI may be a sensitive tool to detect these early stages of plasticity in patient populations.http://dx.doi.org/10.1155/2017/8796239 |
| spellingShingle | Wenwen Song Minhui Dai Lihua Xuan Zhijian Cao Sisi Zhou Courtney Lang Kun Lv Maosheng Xu Jian Kong Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy Neural Plasticity |
| title | Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy |
| title_full | Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy |
| title_fullStr | Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy |
| title_full_unstemmed | Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy |
| title_short | Sensorimotor Cortical Neuroplasticity in the Early Stage of Bell’s Palsy |
| title_sort | sensorimotor cortical neuroplasticity in the early stage of bell s palsy |
| url | http://dx.doi.org/10.1155/2017/8796239 |
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