Comparison of Socal Score and Hasford Score Against the Response of Imatinib Mesylate Therapy in Patients with Chronic Granulocytic Leukemia in dr. Saiful Anwar Hospital Malang
Introduction. The Socal and Hasford scores developed before the era of tirosine kinase inhibitor (TKI) therapy to provide predictions and prognosis for the results of therapy for chronic myeloid leukemia patients (CML). Until now the superiority of Socal and Hasford scores is still debated in predic...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2019-12-01
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| Series: | Jurnal Penyakit Dalam Indonesia |
| Subjects: | |
| Online Access: | http://jurnalpenyakitdalam.ui.ac.id/index.php/jpdi/article/view/332/206 |
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| Summary: | Introduction. The Socal and Hasford scores developed before the era of tirosine kinase inhibitor (TKI) therapy to provide predictions and prognosis for the results of therapy for chronic myeloid leukemia patients (CML). Until now the superiority of Socal and Hasford scores is still debated in predicting the results of therapy in the era of TKI. Imatinib mesylat is a first line TKI in the treatment of CML. This study aims to determine the superior predictive score in predicting hematological and molecular response of patients treated with imatinib mesylate.
Methods. A survey study was conducted with data taken retrospectively from medical records. Subjects were chronic phase LGK patients who had at least been given imatinib mesylate therapy for 12 months. Calculation of Socal and Hasford scores was carried out based on patient data when first receiving Imatinib. To see the difference in distribution between the two scores, a marginal homogeneity statistic was used. To see the process of changing the response of patients treated with Imatinib, a suitability test using chi-square and Fischer was conducted with a significant p value, p <0.05.
Results. There were 52 samples which male : female ratio was 1,4 : 1. The average age when subject was diagnosed with CML was 43 years. The distribution of scores on Socal scores was highest in the high risk group while the Hasford score was highest in the moderate risk group. The prediction of the Socal score towards the achievement of CHR was 44,5%, 38,1%, 9,1% respectively for low, medium, and high risks. The Hasford score prediction for CHR achievement was obtained by 47,1%, 23,1%, 0% for low, medium and high risks. The prediction of the Socal score on the achievement of MMR was 44,4%, 58,8%, 100% for low, medium and high risks. The Hasford score prediction on the achievement of MMR was 78,6%, 47,6%, 62,5% for low, medium and high risk respectively. From the chi-square statistic test, there was no significant difference between Hasford and Socal scores (based on the high and low scores associated with hematological response at the 3rd month and molecular response at 12th month), with p > 0,05.
Conclusion. There was no significant difference between Hasford and Socal scores in predicting hematological responses and molecular responses of chronic CML patients. Socal scores and Hasford scores can be used to predict hematological and molecular responses in chronic CML patients treated with imatinib mesylate. |
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| ISSN: | 2406-8969 2549-0621 |