Assessment of circulating tumor DNA in patients with locally advanced rectal cancer treated with neoadjuvant therapy

Assessment of circulating tumor DNA in patients with locally advanced rectal cancer treated with neoadjuvant therapy

Abstract Post-neoadjuvant therapy (post-NAT) and post-surgical circulating tumor DNA (ctDNA) risk stratification may enhance the management of patients with locally advanced rectal cancer (LARC). In this study, we assessed the prognostic value of ctDNA-based MRD detection in LARC patients using a pe...

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Bibliographic Details
Main Authors: Chiara Molinari, Giorgia Marisi, George Laliotis, Erik Spickard, Ilario Giovanni Rapposelli, Elisabetta Petracci, Giby V. George, Punashi Dutta, Shruti Sharma, Meenakshi Malhotra, Andrea Prochowski Iamurri, Giacomo Feliciani, Minetta C. Liu, Paola Ulivi, Matteo Canale, Luca Saragoni, Graziana Gallo, Giovanni Luca Frassineti, Margherita Muratore, Antonino Romeo, Adham Jurdi, Giovanni Martinelli, Alessandro Passardi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Circulating tumor DNA
Locally advanced rectal cancer
Biomarker
Neoadjuvant therapy
NAR score
Online Access:https://doi.org/10.1038/s41598-024-80855-8
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