Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models
Non-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-04-01
|
| Series: | Frontiers in Transplantation |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/frtra.2025.1576549/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850196965643517952 |
|---|---|
| author | Douglas J. Anderson Jayme E. Locke |
| author_facet | Douglas J. Anderson Jayme E. Locke |
| author_sort | Douglas J. Anderson |
| collection | DOAJ |
| description | Non-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the xenograft in a human decedent or non-human primate. Additionally, we will discuss the pharmacologic agents typically employed in each model, highlighting both the ability of the decedent model to test clinically-relevant medication strategies that may be impossible in non-human primates due to species-specificity. |
| format | Article |
| id | doaj-art-197d42a41a3f43bfad96563d243bef2b |
| institution | OA Journals |
| issn | 2813-2440 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Transplantation |
| spelling | doaj-art-197d42a41a3f43bfad96563d243bef2b2025-08-20T02:13:19ZengFrontiers Media S.A.Frontiers in Transplantation2813-24402025-04-01410.3389/frtra.2025.15765491576549Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate modelsDouglas J. Anderson0Jayme E. Locke1Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, United StatesNYU Langone Health, New York, NY, United StatesNon-human primates and decedent humans have emerged as the two principal translational models in xenotransplantation. Each model has differing advantages and drawbacks. In this manuscript, we will compare and contrast the relative strengths of each model, focusing on the physiologic function of the xenograft in a human decedent or non-human primate. Additionally, we will discuss the pharmacologic agents typically employed in each model, highlighting both the ability of the decedent model to test clinically-relevant medication strategies that may be impossible in non-human primates due to species-specificity.https://www.frontiersin.org/articles/10.3389/frtra.2025.1576549/fullxenotransplantkidneyrenal physiologypharmacokineticsnon-human primatedecedent model |
| spellingShingle | Douglas J. Anderson Jayme E. Locke Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models Frontiers in Transplantation xenotransplant kidney renal physiology pharmacokinetics non-human primate decedent model |
| title | Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models |
| title_full | Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models |
| title_fullStr | Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models |
| title_full_unstemmed | Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models |
| title_short | Pre-clinical xenotransplantation: physiology and pharmacy in human decedent and non-human primate models |
| title_sort | pre clinical xenotransplantation physiology and pharmacy in human decedent and non human primate models |
| topic | xenotransplant kidney renal physiology pharmacokinetics non-human primate decedent model |
| url | https://www.frontiersin.org/articles/10.3389/frtra.2025.1576549/full |
| work_keys_str_mv | AT douglasjanderson preclinicalxenotransplantationphysiologyandpharmacyinhumandecedentandnonhumanprimatemodels AT jaymeelocke preclinicalxenotransplantationphysiologyandpharmacyinhumandecedentandnonhumanprimatemodels |