Gut–X axis
Abstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bon...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-02-01
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| Series: | iMeta |
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| Online Access: | https://doi.org/10.1002/imt2.270 |
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| author | Xu Lin Zuxiang Yu Yang Liu Changzhou Li Hui Hu Jia‐Chun Hu Mian Liu Qin Yang Peng Gu Jiaxin Li Kutty Selva Nandakumar Gaofei Hu Qi Zhang Xinyu Chen Huihui Ma Wenye Huang Gaofeng Wang Yan Wang Liping Huang Wenjuan Wu Ning‐Ning Liu Chenhong Zhang Xingyin Liu Leming Zheng Peng Chen |
| author_facet | Xu Lin Zuxiang Yu Yang Liu Changzhou Li Hui Hu Jia‐Chun Hu Mian Liu Qin Yang Peng Gu Jiaxin Li Kutty Selva Nandakumar Gaofei Hu Qi Zhang Xinyu Chen Huihui Ma Wenye Huang Gaofeng Wang Yan Wang Liping Huang Wenjuan Wu Ning‐Ning Liu Chenhong Zhang Xingyin Liu Leming Zheng Peng Chen |
| author_sort | Xu Lin |
| collection | DOAJ |
| description | Abstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the “gut–X axis” concept to describe the linkages between the gut and other organs and discussed the latest findings related to the “gut–X axis,” including the underlying modulatory mechanisms and potential clinical intervention strategies. |
| format | Article |
| id | doaj-art-197cea4838f14e149d2d140e5190e2b4 |
| institution | OA Journals |
| issn | 2770-596X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj-art-197cea4838f14e149d2d140e5190e2b42025-08-20T02:03:47ZengWileyiMeta2770-596X2025-02-0141n/an/a10.1002/imt2.270Gut–X axisXu Lin0Zuxiang Yu1Yang Liu2Changzhou Li3Hui Hu4Jia‐Chun Hu5Mian Liu6Qin Yang7Peng Gu8Jiaxin Li9Kutty Selva Nandakumar10Gaofei Hu11Qi Zhang12Xinyu Chen13Huihui Ma14Wenye Huang15Gaofeng Wang16Yan Wang17Liping Huang18Wenjuan Wu19Ning‐Ning Liu20Chenhong Zhang21Xingyin Liu22Leming Zheng23Peng Chen24Department of Endocrinology and Metabolism Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) Foshan City 528308 ChinaState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 ChinaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 ChinaDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 ChinaDepartment of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 ChinaDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 ChinaDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 ChinaDepartment of Medical Biochemistry and Biophysics Karolinska Institute Stockholm 17177 SwedenState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 ChinaState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 ChinaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 ChinaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 ChinaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 ChinaDepartment of Plastic and Aesthetic Surgery, Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College Beijing 100050 ChinaDepartment of Obstetrics and Gynecology, Nanfang Hospital Southern Medical University Guangzhou 510515 ChinaDepartment of Laboratory Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai 200123 ChinaState Key Laboratory of Systems Medicine for Cancer, Center for Single‐Cell Omics, School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai 200025 ChinaState Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200240 ChinaState Key Laboratory of Reproductive Medicine and Offsprings Health, Center for Global Health Nanjing Medical University Nanjing 211166 ChinaState Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, The Institute of Cardiovascular Sciences and Institute of Systems Biomedicine Peking University Beijing 100191 ChinaDepartment of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences Southern Medical University Guangzhou 510515 ChinaAbstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the “gut–X axis” concept to describe the linkages between the gut and other organs and discussed the latest findings related to the “gut–X axis,” including the underlying modulatory mechanisms and potential clinical intervention strategies.https://doi.org/10.1002/imt2.270bonebraingutheartkidneyliver |
| spellingShingle | Xu Lin Zuxiang Yu Yang Liu Changzhou Li Hui Hu Jia‐Chun Hu Mian Liu Qin Yang Peng Gu Jiaxin Li Kutty Selva Nandakumar Gaofei Hu Qi Zhang Xinyu Chen Huihui Ma Wenye Huang Gaofeng Wang Yan Wang Liping Huang Wenjuan Wu Ning‐Ning Liu Chenhong Zhang Xingyin Liu Leming Zheng Peng Chen Gut–X axis iMeta bone brain gut heart kidney liver |
| title | Gut–X axis |
| title_full | Gut–X axis |
| title_fullStr | Gut–X axis |
| title_full_unstemmed | Gut–X axis |
| title_short | Gut–X axis |
| title_sort | gut x axis |
| topic | bone brain gut heart kidney liver |
| url | https://doi.org/10.1002/imt2.270 |
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