Gut–X axis

Gut–X axis

Abstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bon...

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Main Authors: Xu Lin, Zuxiang Yu, Yang Liu, Changzhou Li, Hui Hu, Jia‐Chun Hu, Mian Liu, Qin Yang, Peng Gu, Jiaxin Li, Kutty Selva Nandakumar, Gaofei Hu, Qi Zhang, Xinyu Chen, Huihui Ma, Wenye Huang, Gaofeng Wang, Yan Wang, Liping Huang, Wenjuan Wu, Ning‐Ning Liu, Chenhong Zhang, Xingyin Liu, Leming Zheng, Peng Chen
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:iMeta
Subjects:
bone
brain
gut
heart
kidney
liver
Online Access:https://doi.org/10.1002/imt2.270
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Summary:Abstract Recent advances in understanding the modulatory functions of gut and gut microbiota on human diseases facilitated our focused attention on the contribution of the gut to the pathophysiological alterations of many extraintestinal organs, including the liver, heart, brain, lungs, kidneys, bone, skin, reproductive, and endocrine systems. In this review, we applied the “gut–X axis” concept to describe the linkages between the gut and other organs and discussed the latest findings related to the “gut–X axis,” including the underlying modulatory mechanisms and potential clinical intervention strategies.
ISSN:2770-596X

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