Features of Human Herpesvirus-6A and -6B Entry
Human herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species. The process of herpesvirus entry into target cel...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2012/384069 |
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| author | Takahiro Maeki Yasuko Mori |
| author_facet | Takahiro Maeki Yasuko Mori |
| author_sort | Takahiro Maeki |
| collection | DOAJ |
| description | Human herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species. The process of herpesvirus entry into target cells is complicated, and in the case of HHV-6A and HHV-6B, the detailed mechanism remains to be elucidated, although both viruses are known to enter cells via endocytosis. In this paper, (1) findings about the cellular receptor and its ligand for HHV-6A and HHV-6B are summarized, and (2) a schematic model of HHV-6A’s replication cycle, including its entry, is presented. In addition, (3) reports showing the importance of lipids in both the HHV-6A envelope and target-cell membrane for viral entry are reviewed, and (4) glycoproteins involved in cell fusion are discussed. |
| format | Article |
| id | doaj-art-19788e38afdc410190b69b0a8bb71889 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-19788e38afdc410190b69b0a8bb718892025-02-03T01:30:29ZengWileyAdvances in Virology1687-86391687-86472012-01-01201210.1155/2012/384069384069Features of Human Herpesvirus-6A and -6B EntryTakahiro Maeki0Yasuko Mori1Division of Clinical Virology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Clinical Virology, Kobe University Graduate School of Medicine, Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanHuman herpesvirus-6 (HHV-6) is a T lymphotropic herpesvirus belonging to the Betaherpesvirinae subfamily. HHV-6 was long classified into variants A and B (HHV-6A and HHV-6B); however, recently, HHV-6A and HHV-6B were reclassified as different species. The process of herpesvirus entry into target cells is complicated, and in the case of HHV-6A and HHV-6B, the detailed mechanism remains to be elucidated, although both viruses are known to enter cells via endocytosis. In this paper, (1) findings about the cellular receptor and its ligand for HHV-6A and HHV-6B are summarized, and (2) a schematic model of HHV-6A’s replication cycle, including its entry, is presented. In addition, (3) reports showing the importance of lipids in both the HHV-6A envelope and target-cell membrane for viral entry are reviewed, and (4) glycoproteins involved in cell fusion are discussed.http://dx.doi.org/10.1155/2012/384069 |
| spellingShingle | Takahiro Maeki Yasuko Mori Features of Human Herpesvirus-6A and -6B Entry Advances in Virology |
| title | Features of Human Herpesvirus-6A and -6B Entry |
| title_full | Features of Human Herpesvirus-6A and -6B Entry |
| title_fullStr | Features of Human Herpesvirus-6A and -6B Entry |
| title_full_unstemmed | Features of Human Herpesvirus-6A and -6B Entry |
| title_short | Features of Human Herpesvirus-6A and -6B Entry |
| title_sort | features of human herpesvirus 6a and 6b entry |
| url | http://dx.doi.org/10.1155/2012/384069 |
| work_keys_str_mv | AT takahiromaeki featuresofhumanherpesvirus6aand6bentry AT yasukomori featuresofhumanherpesvirus6aand6bentry |