Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals
Electrospinning is a promising drying technology providing a rapid and gentle drying at ambient temperature, thus electrospinning of polyvinyl alcohol aqueous solutions was investigated for the solid formulation of biopharmaceuticals. The commonly used single-needle electrospinning does not have ade...
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| Format: | Article |
| Language: | English |
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Budapest University of Technology and Economics
2019-07-01
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| Series: | eXPRESS Polymer Letters |
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| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0009793&mi=cd |
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| author | E. Hirsch P. Vass B. Demuth Zs. Petho E. Bitay S. K. Andersen T. Vigh G. Verreck K. Molnar Zs. K. Nagy Gy. Marosi |
| author_facet | E. Hirsch P. Vass B. Demuth Zs. Petho E. Bitay S. K. Andersen T. Vigh G. Verreck K. Molnar Zs. K. Nagy Gy. Marosi |
| author_sort | E. Hirsch |
| collection | DOAJ |
| description | Electrospinning is a promising drying technology providing a rapid and gentle drying at ambient temperature, thus electrospinning of polyvinyl alcohol aqueous solutions was investigated for the solid formulation of biopharmaceuticals. The commonly used single-needle electrospinning does not have adequate productivity to satisfy the industrial requirements, therefore our aim was to study the scale-up of the technology by using high-speed electrospinning. High molecular weight polyethylene oxide as a secondary polymer was applied to enhance the fiber formation of polyvinyl alcohol. While polyvinyl alcohol-polyethylene oxide formulations resulted in adequate fiber formation it was not possible to process them further as the friability of the fibers was too low. In order to increase the friability, the effect of adding various sugars (mannitol, glucose, lactose, saccharose, and trehalose) was investigated. The results showed that mannitol was the best friability enhancing excipient because of its crystallinity and low moisture content in the fibrous sample. In contrast, glucose, lactose, saccharose, and trehalose were amorphous with higher moisture content and fibers containing these were grindable only after post-drying. |
| format | Article |
| id | doaj-art-1978142c471d4508a4ef3d19c32a9b50 |
| institution | Kabale University |
| issn | 1788-618X |
| language | English |
| publishDate | 2019-07-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-1978142c471d4508a4ef3d19c32a9b502025-08-20T03:32:58ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2019-07-0113759060310.3144/expresspolymlett.2019.50Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticalsE. HirschP. VassB. DemuthZs. PethoE. BitayS. K. AndersenT. VighG. VerreckK. MolnarZs. K. NagyGy. MarosiElectrospinning is a promising drying technology providing a rapid and gentle drying at ambient temperature, thus electrospinning of polyvinyl alcohol aqueous solutions was investigated for the solid formulation of biopharmaceuticals. The commonly used single-needle electrospinning does not have adequate productivity to satisfy the industrial requirements, therefore our aim was to study the scale-up of the technology by using high-speed electrospinning. High molecular weight polyethylene oxide as a secondary polymer was applied to enhance the fiber formation of polyvinyl alcohol. While polyvinyl alcohol-polyethylene oxide formulations resulted in adequate fiber formation it was not possible to process them further as the friability of the fibers was too low. In order to increase the friability, the effect of adding various sugars (mannitol, glucose, lactose, saccharose, and trehalose) was investigated. The results showed that mannitol was the best friability enhancing excipient because of its crystallinity and low moisture content in the fibrous sample. In contrast, glucose, lactose, saccharose, and trehalose were amorphous with higher moisture content and fibers containing these were grindable only after post-drying.http://www.expresspolymlett.com/letolt.php?file=EPL-0009793&mi=cdNanomaterialsElectrospinningScale-upBiopharmaceuticalsOral formulation |
| spellingShingle | E. Hirsch P. Vass B. Demuth Zs. Petho E. Bitay S. K. Andersen T. Vigh G. Verreck K. Molnar Zs. K. Nagy Gy. Marosi Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals eXPRESS Polymer Letters Nanomaterials Electrospinning Scale-up Biopharmaceuticals Oral formulation |
| title | Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals |
| title_full | Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals |
| title_fullStr | Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals |
| title_full_unstemmed | Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals |
| title_short | Electrospinning scale-up and formulation development of PVA nanofibers aiming oral delivery of biopharmaceuticals |
| title_sort | electrospinning scale up and formulation development of pva nanofibers aiming oral delivery of biopharmaceuticals |
| topic | Nanomaterials Electrospinning Scale-up Biopharmaceuticals Oral formulation |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0009793&mi=cd |
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