YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

YTHDF proteins and m6A-RNA clients undergo autophagic turnover during contact inhibition

Summary: The YTHDF protein family plays a critical role in cancer development by recognizing and regulating the stability of N6-methyladenosine (m6A)-modified RNA. Here, we reveal an autophagy-dependent mechanism controlling YTHDF protein levels. Using contact inhibition as a cellular model system,...

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Main Authors: Hung Ho-Xuan, Astrid Bruckmann, Lautaro Natali, Cristian Prieto-Garcia, Jan F.M. Stuke, Lorene Brunello, Alexandre Vicente, Alexander Pfab, Hagen Wesseling, Sara Cano-Franco, Anshu Khatri, Simone Larivera, Pablo Sanz-Martinez, Benjamin de la Cruz-Thea, Anne-Claire Jacomin, Jan Prochazka, Regina Feederle, Volker Dötsch, Radislav Sedlacek, Gerhard Hummer, Stefanie Kaiser, Ivan Dikic, Melina M. Musri, Gunter Meister, Alexandra Stolz
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Cell Reports
Subjects:
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725009593
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