N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine
The human malaria is widely distributed in the Middle East, Asia, the western Pacific, and Central and South America. Plasmodium vivax started to have the attention of many researchers since it is causing diseases to millions of people and several reports of severe malaria cases have been noticed in...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/965841 |
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| author | Fernanda G. Versiani Maria E. Almeida Luis A. Mariuba Patricia P. Orlandi Paulo A. Nogueira |
| author_facet | Fernanda G. Versiani Maria E. Almeida Luis A. Mariuba Patricia P. Orlandi Paulo A. Nogueira |
| author_sort | Fernanda G. Versiani |
| collection | DOAJ |
| description | The human malaria is widely distributed in the Middle East, Asia, the western Pacific, and Central and South America. Plasmodium vivax started to have the attention of many researchers since it is causing diseases to millions of people and several reports of severe malaria cases have been noticed in the last few years. The lack of in vitro cultures for P. vivax represents a major delay in developing a functional malaria vaccine. One of the major candidates to antimalarial vaccine is the merozoite surface protein-1 (MSP1), which is expressed abundantly on the merozoite surface and capable of activating the host protective immunity. Studies have shown that MSP-1 possesses highly immunogenic fragments, capable of generating immune response and protection in natural infection in endemic regions. This paper shows humoral immune response to different proteins of PvMSP1 and the statement of N-terminal to be added to the list of potential candidates for malaria vivax vaccine. |
| format | Article |
| id | doaj-art-1961b175d3734411900ed460c7b0a2f2 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-1961b175d3734411900ed460c7b0a2f22025-02-03T05:53:45ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/965841965841N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax VaccineFernanda G. Versiani0Maria E. Almeida1Luis A. Mariuba2Patricia P. Orlandi3Paulo A. Nogueira4Universidade Federal do Amazonas, Avenida General Rodrigo Octávio Jordão Ramos 3000, Campus Universitário, Coroado I, 69077-000 Manaus, AM, BrazilUniversidade Federal do Amazonas, Avenida General Rodrigo Octávio Jordão Ramos 3000, Campus Universitário, Coroado I, 69077-000 Manaus, AM, BrazilInstituto Leônidas e Maria Deane-Fiocruz, Rua Teresina 476, 69057-070 Manaus, AM, BrazilInstituto Leônidas e Maria Deane-Fiocruz, Rua Teresina 476, 69057-070 Manaus, AM, BrazilInstituto Leônidas e Maria Deane-Fiocruz, Rua Teresina 476, 69057-070 Manaus, AM, BrazilThe human malaria is widely distributed in the Middle East, Asia, the western Pacific, and Central and South America. Plasmodium vivax started to have the attention of many researchers since it is causing diseases to millions of people and several reports of severe malaria cases have been noticed in the last few years. The lack of in vitro cultures for P. vivax represents a major delay in developing a functional malaria vaccine. One of the major candidates to antimalarial vaccine is the merozoite surface protein-1 (MSP1), which is expressed abundantly on the merozoite surface and capable of activating the host protective immunity. Studies have shown that MSP-1 possesses highly immunogenic fragments, capable of generating immune response and protection in natural infection in endemic regions. This paper shows humoral immune response to different proteins of PvMSP1 and the statement of N-terminal to be added to the list of potential candidates for malaria vivax vaccine.http://dx.doi.org/10.1155/2013/965841 |
| spellingShingle | Fernanda G. Versiani Maria E. Almeida Luis A. Mariuba Patricia P. Orlandi Paulo A. Nogueira N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine Clinical and Developmental Immunology |
| title | N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine |
| title_full | N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine |
| title_fullStr | N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine |
| title_full_unstemmed | N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine |
| title_short | N-Terminal Plasmodium vivax Merozoite Surface Protein-1, a Potential Subunit for Malaria Vivax Vaccine |
| title_sort | n terminal plasmodium vivax merozoite surface protein 1 a potential subunit for malaria vivax vaccine |
| url | http://dx.doi.org/10.1155/2013/965841 |
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