The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis
Coronary computed tomography angiography (CCTA) is the gold standard method for detecting the presence of coronary plaque and stenosis in atherosclerosis. However, the nephrotoxic effects of contrast agents applied during angiography and the adverse effects of radiation are known. Alternative diagno...
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| Format: | Article |
| Language: | English |
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Sciendo
2025-07-01
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| Series: | Romanian Journal of Laboratory Medicine |
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| Online Access: | https://doi.org/10.2478/rrlm-2025-0015 |
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| author | Sungur Neslihan Muhtaroğlu Sabahattin Keti Didem Barlak Imamoğlu Hakan |
| author_facet | Sungur Neslihan Muhtaroğlu Sabahattin Keti Didem Barlak Imamoğlu Hakan |
| author_sort | Sungur Neslihan |
| collection | DOAJ |
| description | Coronary computed tomography angiography (CCTA) is the gold standard method for detecting the presence of coronary plaque and stenosis in atherosclerosis. However, the nephrotoxic effects of contrast agents applied during angiography and the adverse effects of radiation are known. Alternative diagnostic tools are always needed to evaluate coronary arteries. Therefore, combining the results of CCTA with Lipoprotein-associated phospholipase A2 (Lp-PLA2) and Matrix metalloproteinase (MMP)-9, which are thought to be associated with atherosclerotic plaque, may reduce cardiovascular events in patients with suspected atherosclerosis. |
| format | Article |
| id | doaj-art-1951c4af62b64fddb0a9c4fafefee06e |
| institution | Kabale University |
| issn | 2284-5623 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj-art-1951c4af62b64fddb0a9c4fafefee06e2025-08-20T03:41:10ZengSciendoRomanian Journal of Laboratory Medicine2284-56232025-07-0133314315010.2478/rrlm-2025-0015The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosisSungur Neslihan0Muhtaroğlu Sabahattin1Keti Didem Barlak2Imamoğlu Hakan31Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey1Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey1Department of Biochemistry, Faculty of Medicine, Erciyes University, Kayseri, Turkey2Department of Radiology, Faculty of Medicine, Erciyes University, Kayseri, TurkeyCoronary computed tomography angiography (CCTA) is the gold standard method for detecting the presence of coronary plaque and stenosis in atherosclerosis. However, the nephrotoxic effects of contrast agents applied during angiography and the adverse effects of radiation are known. Alternative diagnostic tools are always needed to evaluate coronary arteries. Therefore, combining the results of CCTA with Lipoprotein-associated phospholipase A2 (Lp-PLA2) and Matrix metalloproteinase (MMP)-9, which are thought to be associated with atherosclerotic plaque, may reduce cardiovascular events in patients with suspected atherosclerosis.https://doi.org/10.2478/rrlm-2025-0015coronary ct angiographycoronary plaquelp-pla2mmp-9sdldl |
| spellingShingle | Sungur Neslihan Muhtaroğlu Sabahattin Keti Didem Barlak Imamoğlu Hakan The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis Romanian Journal of Laboratory Medicine coronary ct angiography coronary plaque lp-pla2 mmp-9 sdldl |
| title | The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis |
| title_full | The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis |
| title_fullStr | The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis |
| title_full_unstemmed | The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis |
| title_short | The diagnostic value of lipoprotein-related phospholipase A2 and matrix metalloproteinase-9 in identifying patients with coronary plaque or stenosis |
| title_sort | diagnostic value of lipoprotein related phospholipase a2 and matrix metalloproteinase 9 in identifying patients with coronary plaque or stenosis |
| topic | coronary ct angiography coronary plaque lp-pla2 mmp-9 sdldl |
| url | https://doi.org/10.2478/rrlm-2025-0015 |
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