Macrophage Heterogeneity in Respiratory Diseases
Macrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas excha...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/769214 |
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| _version_ | 1832551651420930048 |
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| author | Carian E. Boorsma Christina Draijer Barbro N. Melgert |
| author_facet | Carian E. Boorsma Christina Draijer Barbro N. Melgert |
| author_sort | Carian E. Boorsma |
| collection | DOAJ |
| description | Macrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas exchange against microbial threats and excessive tissue responses. Phenotypical changes of macrophages within the lung are found in many respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. This paper will give an overview of what macrophage phenotypes have been described, what their known functions are, what is known about their presence in the different obstructive and restrictive respiratory diseases (asthma, COPD, pulmonary fibrosis), and how they are thought to contribute to the etiology and resolution of these diseases. |
| format | Article |
| id | doaj-art-193bea6b66f2415d93acca0816ea2bc7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-193bea6b66f2415d93acca0816ea2bc72025-02-03T06:00:51ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/769214769214Macrophage Heterogeneity in Respiratory DiseasesCarian E. Boorsma0Christina Draijer1Barbro N. Melgert2Department of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The NetherlandsDepartment of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The NetherlandsDepartment of Pharmacokinetics, Toxicology and Targeting, Groningen Research Institute for Pharmacy, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The NetherlandsMacrophages are among the most abundant cells in the respiratory tract, and they can have strikingly different phenotypes within this environment. Our knowledge of the different phenotypes and their functions in the lung is sketchy at best, but they appear to be linked to the protection of gas exchange against microbial threats and excessive tissue responses. Phenotypical changes of macrophages within the lung are found in many respiratory diseases including asthma, chronic obstructive pulmonary disease (COPD), and pulmonary fibrosis. This paper will give an overview of what macrophage phenotypes have been described, what their known functions are, what is known about their presence in the different obstructive and restrictive respiratory diseases (asthma, COPD, pulmonary fibrosis), and how they are thought to contribute to the etiology and resolution of these diseases.http://dx.doi.org/10.1155/2013/769214 |
| spellingShingle | Carian E. Boorsma Christina Draijer Barbro N. Melgert Macrophage Heterogeneity in Respiratory Diseases Mediators of Inflammation |
| title | Macrophage Heterogeneity in Respiratory Diseases |
| title_full | Macrophage Heterogeneity in Respiratory Diseases |
| title_fullStr | Macrophage Heterogeneity in Respiratory Diseases |
| title_full_unstemmed | Macrophage Heterogeneity in Respiratory Diseases |
| title_short | Macrophage Heterogeneity in Respiratory Diseases |
| title_sort | macrophage heterogeneity in respiratory diseases |
| url | http://dx.doi.org/10.1155/2013/769214 |
| work_keys_str_mv | AT carianeboorsma macrophageheterogeneityinrespiratorydiseases AT christinadraijer macrophageheterogeneityinrespiratorydiseases AT barbronmelgert macrophageheterogeneityinrespiratorydiseases |