Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases
Cardiovascular diseases are an important group of diseases that seriously affect quality of life. Thus, their treatment warrants further study. Heparin-binding protein (HBP) is a granulocyte protein derived from neutrophils. When an infection occurs, neutrophils release HBP, which can lead to elevat...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2020/9575373 |
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| author | Yufeng Cai Xueyan Zhang Jie Shen Boyue Jiang Dehua Hu Mingyi Zhao |
| author_facet | Yufeng Cai Xueyan Zhang Jie Shen Boyue Jiang Dehua Hu Mingyi Zhao |
| author_sort | Yufeng Cai |
| collection | DOAJ |
| description | Cardiovascular diseases are an important group of diseases that seriously affect quality of life. Thus, their treatment warrants further study. Heparin-binding protein (HBP) is a granulocyte protein derived from neutrophils. When an infection occurs, neutrophils release HBP, which can lead to elevated HBP levels in the blood. Therefore, HBP family members are said to be important indicators of infection. However, basic evidence is still lacking to confirm the possible relationship between HBP and cardiovascular diseases. Using bioinformatics methods, we investigated the role of the HBP network in normal hearts and hearts from patients with cardiovascular disease. First, we used the Open Targets database to obtain a list of HBP-encoding mRNAs related to atherosclerosis, myocarditis, myocardial infarction, and myocardial ischemia. Then, we constructed an HBP gene interaction network map using STRING. Clustering coefficients were calculated using Cytoscape, and MCODE was used for subnet analysis. Finally, the proposed interstitial network of HBPs was established and analyzed by Metascape enrichment analysis of the relevant signaling pathways. The aggregation coefficient of the HBP interaction network was higher among hearts with the four cardiovascular diseases, atherosclerosis (0.496), myocarditis (0.631), myocardial infarction (0.532), and myocardial ischemia (0.551), than in normal hearts. Metascape analysis showed that “NABA_MATRISOME_ASSOCIATED” was a typical pathway with the highest p value associated with epithelialization in all four diseases. Moreover, a large number of important HBPs were identified that may be significant for the treatment of these diseases. Therefore, HBPs do have a highly atopic connectivity network in cardiovascular diseases, and specific HBPs or signaling pathways may be used as targets for the development of new treatments for cardiovascular diseases. |
| format | Article |
| id | doaj-art-193659e421c947f7ae2e73a77d68e4b7 |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-193659e421c947f7ae2e73a77d68e4b72025-08-20T02:02:06ZengWileyCardiology Research and Practice2090-80162090-05972020-01-01202010.1155/2020/95753739575373Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular DiseasesYufeng Cai0Xueyan Zhang1Jie Shen2Boyue Jiang3Dehua Hu4Mingyi Zhao5Department of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, ChinaXiangya School of Life Science, Central South University, Changsha, Hunan, ChinaDepartment of Pediatrics, The Third Xiangya Hospital, Central South University, Hunan, Changsha, ChinaCardiovascular diseases are an important group of diseases that seriously affect quality of life. Thus, their treatment warrants further study. Heparin-binding protein (HBP) is a granulocyte protein derived from neutrophils. When an infection occurs, neutrophils release HBP, which can lead to elevated HBP levels in the blood. Therefore, HBP family members are said to be important indicators of infection. However, basic evidence is still lacking to confirm the possible relationship between HBP and cardiovascular diseases. Using bioinformatics methods, we investigated the role of the HBP network in normal hearts and hearts from patients with cardiovascular disease. First, we used the Open Targets database to obtain a list of HBP-encoding mRNAs related to atherosclerosis, myocarditis, myocardial infarction, and myocardial ischemia. Then, we constructed an HBP gene interaction network map using STRING. Clustering coefficients were calculated using Cytoscape, and MCODE was used for subnet analysis. Finally, the proposed interstitial network of HBPs was established and analyzed by Metascape enrichment analysis of the relevant signaling pathways. The aggregation coefficient of the HBP interaction network was higher among hearts with the four cardiovascular diseases, atherosclerosis (0.496), myocarditis (0.631), myocardial infarction (0.532), and myocardial ischemia (0.551), than in normal hearts. Metascape analysis showed that “NABA_MATRISOME_ASSOCIATED” was a typical pathway with the highest p value associated with epithelialization in all four diseases. Moreover, a large number of important HBPs were identified that may be significant for the treatment of these diseases. Therefore, HBPs do have a highly atopic connectivity network in cardiovascular diseases, and specific HBPs or signaling pathways may be used as targets for the development of new treatments for cardiovascular diseases.http://dx.doi.org/10.1155/2020/9575373 |
| spellingShingle | Yufeng Cai Xueyan Zhang Jie Shen Boyue Jiang Dehua Hu Mingyi Zhao Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases Cardiology Research and Practice |
| title | Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases |
| title_full | Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases |
| title_fullStr | Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases |
| title_full_unstemmed | Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases |
| title_short | Heparin-Binding Protein: A Novel Biomarker Linking Four Different Cardiovascular Diseases |
| title_sort | heparin binding protein a novel biomarker linking four different cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2020/9575373 |
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