Synthesis and Antifungal Activity of Azetidinone and Thiazolidinones Derivatives of 2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole
2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole [1] was prepared by treatment of KCNS and Br2 on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acety...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2006/186294 |
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| Summary: | 2-Amino-6-(2-naphthalenyl)thiazolo[3,2-d]thiadiazole [1] was prepared by treatment of KCNS and Br2 on 2-Amino-4-(2-naphthalenyl) thiazole. This amine on facile condensation with aromatic aldehydes afford Schiff Base/anils/azomethines(2a-h). These anils on cyclocondensation reaction with chloro acetyl chloride and thio glycolic acid (i.e. mercapto acetic acid) afford 2-azetidinones and 4-thiazolidinones respectively. The prepared compounds have been screened on some stains of fungai. |
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| ISSN: | 0973-4945 2090-9810 |