Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses

Role of astrocytic mu-opioid receptors of the ventrolateral periaqueductal gray in modulating anxiety-like responses

Abstract Background Mu-opioid receptors (MORs) are critical regulators mediating the modulation of several behavioral reactions, including analgesia, addiction, and sedation. Recent studies have reported that MORs are closely associated with mood disorders or anxiety behaviors; however, the underlyi...

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Main Authors: Yinan Du, Aozhuo Zhang, Zhiwei Li, Yukui Zhao, Shuyi Liu, Chunling Wei, Qiaohua Zheng, Yanning Qiao, Yihui Liu, Wei Ren, Jing Han, Zhiqiang Liu, Fei Gao
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Behavioral and Brain Functions
Subjects:
Anxiety
Mu-opioid receptors
Periaqueductal gray
Astrocyte
Calcium signaling
Online Access:https://doi.org/10.1186/s12993-025-00291-0
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