SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS
New untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process i...
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2015-08-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/784 |
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| author | D. S. Esmedlyaeva O. T. Titarenko M. V. Pavlova M. E. Dyakova T. L. Perova |
| author_facet | D. S. Esmedlyaeva O. T. Titarenko M. V. Pavlova M. E. Dyakova T. L. Perova |
| author_sort | D. S. Esmedlyaeva |
| collection | DOAJ |
| description | New untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process is related to unbalanced increase of рro-ММР-1 and ММР-9. At the same time the level of рro-ММР-1 correlates to changes in ROF, activity of proteinases of other classes (serine proteinases) and depends on the dissemination of the disease, while the changes in MMP-9 level are influenced by the massiveness of bacillary excretion. |
| format | Article |
| id | doaj-art-1928f7484c6b4dc7a5c06c4e654ef2b1 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2015-08-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-1928f7484c6b4dc7a5c06c4e654ef2b12025-08-20T02:05:56ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062015-08-0108384210.21292/2075-1230-2015-0-8-38-42784SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSISD. S. Esmedlyaeva0O. T. Titarenko1M. V. Pavlova2M. E. Dyakova3T. L. Perova4St. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologySt. Petersburg Research Institute of PhthisiopulmonologyNew untreated infiltrate pulmonary tuberculosis patients commonly demonstrated the same referent level of MMP-8, MMP-3 and multiple increase of MMP-9 level on the background of diverse changes of inhibiting potential (retaining the reference level of TIMP-1 and reduced α2 -МG). Destructive process is related to unbalanced increase of рro-ММР-1 and ММР-9. At the same time the level of рro-ММР-1 correlates to changes in ROF, activity of proteinases of other classes (serine proteinases) and depends on the dissemination of the disease, while the changes in MMP-9 level are influenced by the massiveness of bacillary excretion.https://www.tibl-journal.com/jour/article/view/784tuberculosismatrix metalloproteinasesextracellular matrix |
| spellingShingle | D. S. Esmedlyaeva O. T. Titarenko M. V. Pavlova M. E. Dyakova T. L. Perova SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS Туберкулез и болезни лёгких tuberculosis matrix metalloproteinases extracellular matrix |
| title | SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS |
| title_full | SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS |
| title_fullStr | SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS |
| title_full_unstemmed | SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS |
| title_short | SYSTEM OF MATRIX METALLOPROTEINASES IN THE EVALUATION OF LUNG TISSUE DESTRUCTION IN TUBERCULOSIS |
| title_sort | system of matrix metalloproteinases in the evaluation of lung tissue destruction in tuberculosis |
| topic | tuberculosis matrix metalloproteinases extracellular matrix |
| url | https://www.tibl-journal.com/jour/article/view/784 |
| work_keys_str_mv | AT dsesmedlyaeva systemofmatrixmetalloproteinasesintheevaluationoflungtissuedestructionintuberculosis AT ottitarenko systemofmatrixmetalloproteinasesintheevaluationoflungtissuedestructionintuberculosis AT mvpavlova systemofmatrixmetalloproteinasesintheevaluationoflungtissuedestructionintuberculosis AT medyakova systemofmatrixmetalloproteinasesintheevaluationoflungtissuedestructionintuberculosis AT tlperova systemofmatrixmetalloproteinasesintheevaluationoflungtissuedestructionintuberculosis |