Skin microbiome engineering: Challenges and opportunities in skin diseases treatment
Abstract The skin microbiome, consisting of a vast array of microorganisms, is essential for human skin health, aiding in barrier protection, immune regulation, wound repair, and defense against pathogens. Disruptions in this microbial balance are closely linked to the onset and worsening of various...
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| Format: | Article |
| Language: | English |
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Wiley
2025-06-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.70012 |
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| _version_ | 1850131296993411072 |
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| author | Yiang Lyu Juntao Shen You Che Lei Dai |
| author_facet | Yiang Lyu Juntao Shen You Che Lei Dai |
| author_sort | Yiang Lyu |
| collection | DOAJ |
| description | Abstract The skin microbiome, consisting of a vast array of microorganisms, is essential for human skin health, aiding in barrier protection, immune regulation, wound repair, and defense against pathogens. Disruptions in this microbial balance are closely linked to the onset and worsening of various skin disorders. This review evaluates the potential of skin microbiome engineering as a therapeutic strategy for treating skin diseases. We discuss nontargeted approaches like probiotics and fecal microbiota transplantation that aim to reshape the microbial community, as well as targeted methods such as phage therapy, phage lysins, and engineered bacteria, which specifically modulate microbial populations or influence the skin environment. These approaches open new avenues for personalized dermatological treatments. Despite significant progress, challenges remain in the clinical translation of microbiome‐based therapies. Safety, standardization, regulatory approval, and long‐term ecological stability must be addressed to ensure efficacy and reproducibility in clinical settings, underscoring the critical need for further research in their dermatological applications. |
| format | Article |
| id | doaj-art-192898e91c444a9a9688f5c99bfdde92 |
| institution | OA Journals |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-192898e91c444a9a9688f5c99bfdde922025-08-20T02:32:27ZengWileyiMetaOmics2996-95062996-95142025-06-0122n/an/a10.1002/imo2.70012Skin microbiome engineering: Challenges and opportunities in skin diseases treatmentYiang Lyu0Juntao Shen1You Che2Lei Dai3CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen ChinaCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen ChinaHKU‐Pasteur Research Pole, School of Public Health, Li Ka Shing Faculty of Medicine The University of Hong Kong ChinaCAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen ChinaAbstract The skin microbiome, consisting of a vast array of microorganisms, is essential for human skin health, aiding in barrier protection, immune regulation, wound repair, and defense against pathogens. Disruptions in this microbial balance are closely linked to the onset and worsening of various skin disorders. This review evaluates the potential of skin microbiome engineering as a therapeutic strategy for treating skin diseases. We discuss nontargeted approaches like probiotics and fecal microbiota transplantation that aim to reshape the microbial community, as well as targeted methods such as phage therapy, phage lysins, and engineered bacteria, which specifically modulate microbial populations or influence the skin environment. These approaches open new avenues for personalized dermatological treatments. Despite significant progress, challenges remain in the clinical translation of microbiome‐based therapies. Safety, standardization, regulatory approval, and long‐term ecological stability must be addressed to ensure efficacy and reproducibility in clinical settings, underscoring the critical need for further research in their dermatological applications.https://doi.org/10.1002/imo2.70012immune modulationmicrobiome engineeringskin barriertargeted therapies |
| spellingShingle | Yiang Lyu Juntao Shen You Che Lei Dai Skin microbiome engineering: Challenges and opportunities in skin diseases treatment iMetaOmics immune modulation microbiome engineering skin barrier targeted therapies |
| title | Skin microbiome engineering: Challenges and opportunities in skin diseases treatment |
| title_full | Skin microbiome engineering: Challenges and opportunities in skin diseases treatment |
| title_fullStr | Skin microbiome engineering: Challenges and opportunities in skin diseases treatment |
| title_full_unstemmed | Skin microbiome engineering: Challenges and opportunities in skin diseases treatment |
| title_short | Skin microbiome engineering: Challenges and opportunities in skin diseases treatment |
| title_sort | skin microbiome engineering challenges and opportunities in skin diseases treatment |
| topic | immune modulation microbiome engineering skin barrier targeted therapies |
| url | https://doi.org/10.1002/imo2.70012 |
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