Screening of household contacts for TB infection in Cote d'Ivoire
SETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation. OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d’Ivoire to evaluate economic implications...
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| Format: | Article |
| Language: | English |
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International Union Against Tuberculosis and Lung Disease (The Union)
2024-01-01
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| Series: | IJTLD Open |
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| Online Access: | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00005 |
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| author | R. K. N’Guessan D. A. B. Orsot J.M. Ahui Brou N. K. Bamba M. E. Tchoutedjem Mefo A. S. Bakayoko |
| author_facet | R. K. N’Guessan D. A. B. Orsot J.M. Ahui Brou N. K. Bamba M. E. Tchoutedjem Mefo A. S. Bakayoko |
| author_sort | R. K. N’Guessan |
| collection | DOAJ |
| description | SETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation. OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d’Ivoire to evaluate economic implications of the implementation of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST). DESIGN: We compared the effectiveness of QuantiFERON-TB Gold Plus (QuantiFERON) with the TST using an economic model previously evaluated in medium TB incidence settings. Principal outcomes relating to TBI screening, as well as the lifetime costs and benefits of the patient cohort, were captured using a decision tree, followed by a Markov model. RESULTS: QuantiFERON proved to be both more effective and less costly than TST. Compared to QuantiFERON, TST use leads to an approximate 33% increase in the lifetime risk of developing active TB. CONCLUSIONS: For household contacts of active TB cases in Côte d’Ivoire, QuantiFERON is cost-effective when compared with TST. R shiny interactive interface enables model customisation for different scenarios, settings, risk groups and TBI screening methods. Further research should be conducted in similar settings to generalise the results. |
| format | Article |
| id | doaj-art-19275703447b4151978916f650f3dfc3 |
| institution | Kabale University |
| issn | 3005-7590 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | International Union Against Tuberculosis and Lung Disease (The Union) |
| record_format | Article |
| series | IJTLD Open |
| spelling | doaj-art-19275703447b4151978916f650f3dfc32025-01-21T09:59:34ZengInternational Union Against Tuberculosis and Lung Disease (The Union)IJTLD Open3005-75902024-01-0111202610.5588/ijtldopen.23.03425Screening of household contacts for TB infection in Cote d'IvoireR. K. N’Guessan0D. A. B. Orsot1J.M. Ahui Brou2N. K. Bamba3M. E. Tchoutedjem Mefo4A. S. Bakayoko5Unité des Mycobactéries Tuberculeuses et Atypiques, Laboratoire National de Référence de la Tuberculose, Institut Pasteur de Côte d'Ivoire, Abidjan,Unité des Mycobactéries Tuberculeuses et Atypiques, Laboratoire National de Référence de la Tuberculose, Institut Pasteur de Côte d'Ivoire, Abidjan,Unité de formation et de recherche (UFR) des Sciences Médicales Université Felix Houphouët-Boigny Service de Pneumologie Centre Hospitalière Universitaire (CHU) de Cocody,Unité des Mycobactéries Tuberculeuses et Atypiques, Laboratoire National de Référence de la Tuberculose, Institut Pasteur de Côte d'Ivoire, Abidjan,Programme National de Lutte contre la Tuberculose AbidjanUFR des Sciences Médicales Université Felix Houphouët-Boigny Service de Pneumologie CHU de Treichville, Abidjan, Côte d'IvoireSETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation. OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d’Ivoire to evaluate economic implications of the implementation of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST). DESIGN: We compared the effectiveness of QuantiFERON-TB Gold Plus (QuantiFERON) with the TST using an economic model previously evaluated in medium TB incidence settings. Principal outcomes relating to TBI screening, as well as the lifetime costs and benefits of the patient cohort, were captured using a decision tree, followed by a Markov model. RESULTS: QuantiFERON proved to be both more effective and less costly than TST. Compared to QuantiFERON, TST use leads to an approximate 33% increase in the lifetime risk of developing active TB. CONCLUSIONS: For household contacts of active TB cases in Côte d’Ivoire, QuantiFERON is cost-effective when compared with TST. R shiny interactive interface enables model customisation for different scenarios, settings, risk groups and TBI screening methods. Further research should be conducted in similar settings to generalise the results.https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00005latent tuberculosis infectionscreeningcostsqalys |
| spellingShingle | R. K. N’Guessan D. A. B. Orsot J.M. Ahui Brou N. K. Bamba M. E. Tchoutedjem Mefo A. S. Bakayoko Screening of household contacts for TB infection in Cote d'Ivoire IJTLD Open latent tuberculosis infection screening costs qalys |
| title | Screening of household contacts for TB infection in Cote d'Ivoire |
| title_full | Screening of household contacts for TB infection in Cote d'Ivoire |
| title_fullStr | Screening of household contacts for TB infection in Cote d'Ivoire |
| title_full_unstemmed | Screening of household contacts for TB infection in Cote d'Ivoire |
| title_short | Screening of household contacts for TB infection in Cote d'Ivoire |
| title_sort | screening of household contacts for tb infection in cote d ivoire |
| topic | latent tuberculosis infection screening costs qalys |
| url | https://www.ingentaconnect.com/contentone/iuatld/ijtldo/2024/00000001/00000001/art00005 |
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