SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY
Applying clinical pharmacology guidelines to the mother-fetus system makes it possible to better understand the specifics of pharmacokinetics during pregnancy. The article illustrates the factors that drive these specific features related to both changes in the boy of a future mother and the presenc...
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| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Union of pediatricians of Russia
2010-09-01
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| Series: | Педиатрическая фармакология |
| Online Access: | https://www.pedpharma.ru/jour/article/view/1095 |
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| _version_ | 1849695674328678400 |
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| author | A.V. Ostrovskaya S.A. Sher |
| author_facet | A.V. Ostrovskaya S.A. Sher |
| author_sort | A.V. Ostrovskaya |
| collection | DOAJ |
| description | Applying clinical pharmacology guidelines to the mother-fetus system makes it possible to better understand the specifics of pharmacokinetics during pregnancy. The article illustrates the factors that drive these specific features related to both changes in the boy of a future mother and the presence of an extra fetal-placental blood circulation, especially the placenta and developing fetus. These factors influence the results of drug-based treatment during the entire gestational period. Thanks to a rapid development of molecular technologies in the last decade, modern medicine has good prospects of answering questions about individual specifics of pharmacokinetics and metabolism of drugs, increased teratogenic risk driven by specifics of genotypes of the mother and fetus. Key words: pharmacokinetics, drugs, pregnancy, placenta, mother-fetus system. (Pediatric Pharmacology. – 2010; 7(5):44-47) |
| format | Article |
| id | doaj-art-19255769a4ee4b0e8969aa6b65505325 |
| institution | DOAJ |
| issn | 1727-5776 2500-3089 |
| language | Russian |
| publishDate | 2010-09-01 |
| publisher | Union of pediatricians of Russia |
| record_format | Article |
| series | Педиатрическая фармакология |
| spelling | doaj-art-19255769a4ee4b0e8969aa6b655053252025-08-20T03:19:42ZrusUnion of pediatricians of RussiaПедиатрическая фармакология1727-57762500-30892010-09-017544471090SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCYA.V. Ostrovskaya0S.A. Sher1Scientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowApplying clinical pharmacology guidelines to the mother-fetus system makes it possible to better understand the specifics of pharmacokinetics during pregnancy. The article illustrates the factors that drive these specific features related to both changes in the boy of a future mother and the presence of an extra fetal-placental blood circulation, especially the placenta and developing fetus. These factors influence the results of drug-based treatment during the entire gestational period. Thanks to a rapid development of molecular technologies in the last decade, modern medicine has good prospects of answering questions about individual specifics of pharmacokinetics and metabolism of drugs, increased teratogenic risk driven by specifics of genotypes of the mother and fetus. Key words: pharmacokinetics, drugs, pregnancy, placenta, mother-fetus system. (Pediatric Pharmacology. – 2010; 7(5):44-47)https://www.pedpharma.ru/jour/article/view/1095 |
| spellingShingle | A.V. Ostrovskaya S.A. Sher SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY Педиатрическая фармакология |
| title | SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY |
| title_full | SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY |
| title_fullStr | SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY |
| title_full_unstemmed | SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY |
| title_short | SPECIFICS OF DRUG PHARMACOKINETICS IN PREGNANCY |
| title_sort | specifics of drug pharmacokinetics in pregnancy |
| url | https://www.pedpharma.ru/jour/article/view/1095 |
| work_keys_str_mv | AT avostrovskaya specificsofdrugpharmacokineticsinpregnancy AT sasher specificsofdrugpharmacokineticsinpregnancy |