ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease
Background. This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). Methods. Relevant studies were identified from digital databases such as Emb...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/5158497 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832554547060408320 |
|---|---|
| author | Qiuxia Han Wenjia Geng Dong Zhang Guangyan Cai Hanyu Zhu |
| author_facet | Qiuxia Han Wenjia Geng Dong Zhang Guangyan Cai Hanyu Zhu |
| author_sort | Qiuxia Han |
| collection | DOAJ |
| description | Background. This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). Methods. Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models. Interstudy heterogeneity was examined using the Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates. Begg’s funnel plot and Egger’s test were applied to inspect potential publication bias among the included studies. Results. The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR=1.51, 95%CI=1.16−1.95; OR=1.43, 95%CI=1.11−1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup. Conclusion. The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients. |
| format | Article |
| id | doaj-art-1925495e7bac4b37b7b94c1678895e7e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-1925495e7bac4b37b7b94c1678895e7e2025-02-03T05:51:11ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/51584975158497ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney DiseaseQiuxia Han0Wenjia Geng1Dong Zhang2Guangyan Cai3Hanyu Zhu4School of Medicine, Nankai University, Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, ChinaDepartment of Nephrology, Guangdong Provincial Hospital of Chinese Medicine, Nephrology Institute of Guangdong Provincial Hospital of Chinese Medicine, The Second Affiliated Hospital of Guangzhou, University of Chinese Medicine, ChinaSchool of Medicine, Nankai University, Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, ChinaSchool of Medicine, Nankai University, Department of Nephrology, The First Medical Centre, Chinese PLA General Hospital, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, ChinaDepartment of Nephrology, The First Medical Centre, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center of Kidney Diseases, Beijing Key Laboratory of Kidney Disease, ChinaBackground. This meta-analysis was performed to obtain a more comprehensive estimation of the role of the single nucleotide polymorphism (SNP) rs2241766 in the ADIPOQ gene in the occurrence of diabetic kidney disease (DKD). Methods. Relevant studies were identified from digital databases such as Embase, PubMed, Medline, Cochrane Library, Google Scholar, WanFang, and Chinese National Knowledge Infrastructure (CNKI). Odds ratios (ORs) with their corresponding 95% confidence intervals (95% CIs) were pooled by means of fixed- or random-effects models. Interstudy heterogeneity was examined using the Q test and I2 statistic, and sensitivity analysis was implemented to test the statistical stability of the overall estimates. Begg’s funnel plot and Egger’s test were applied to inspect potential publication bias among the included studies. Results. The overall ORs reflected a positive correlation between the ADIPOQ rs2241766 polymorphism and susceptibility to DKD in the GG vs. TT and GG vs. TT+TG comparisons (OR=1.51, 95%CI=1.16−1.95; OR=1.43, 95%CI=1.11−1.85). After stratification analyses by ethnicity and disease type, a similar trend was also revealed in the Caucasian and African subgroups as well as in the type 2 diabetes mellitus (T2DM) subgroup. Conclusion. The ADIPOQ rs2241766 polymorphism may be associated with an increased risk of DKD, especially in Caucasian and African populations as well as in T2DM patients.http://dx.doi.org/10.1155/2020/5158497 |
| spellingShingle | Qiuxia Han Wenjia Geng Dong Zhang Guangyan Cai Hanyu Zhu ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease Journal of Diabetes Research |
| title | ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease |
| title_full | ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease |
| title_fullStr | ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease |
| title_full_unstemmed | ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease |
| title_short | ADIPOQ rs2241766 Gene Polymorphism and Predisposition to Diabetic Kidney Disease |
| title_sort | adipoq rs2241766 gene polymorphism and predisposition to diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2020/5158497 |
| work_keys_str_mv | AT qiuxiahan adipoqrs2241766genepolymorphismandpredispositiontodiabetickidneydisease AT wenjiageng adipoqrs2241766genepolymorphismandpredispositiontodiabetickidneydisease AT dongzhang adipoqrs2241766genepolymorphismandpredispositiontodiabetickidneydisease AT guangyancai adipoqrs2241766genepolymorphismandpredispositiontodiabetickidneydisease AT hanyuzhu adipoqrs2241766genepolymorphismandpredispositiontodiabetickidneydisease |