The impact of site-specific DNA methylation in KCNJ11 promoter on type 2 diabetes

The impact of site-specific DNA methylation in KCNJ11 promoter on type 2 diabetes

Aims: This study explores the correlation between site-specific methylation levels of the KCNJ11 promoter and type 2 diabetes mellitus (T2DM), analyzing potential molecular mechanisms. Methods: Thirty patients newly diagnosed with T2DM and 30 healthy controls were selected to determine the CpG methy...

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Bibliographic Details
Main Authors: Mengmeng Zhu, Qiaoliang Huang, Heng Li, Yujie Zhao, Heming Guo, Tao Wang, Xiaodan Liu, Yun Huang, Ji Hu, Chen Fang, Jian Huang
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Heliyon
Subjects:
Type 2 diabetes
DNA methylation
KCNJ11 gene
TCF12 transcription factor
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024159658
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