Modern treatment approaches for erectile dysfunction – review
Erectile dysfunction (ED) is a significant public health issue that affects both patients’ quality of life and their intimate relationships. While phosphodiesterase type 5 inhibitors (PDE5-Is) are the standard first-line treatment, a substantial proportion of patients fail to achieve satisfactory re...
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| Format: | Article |
| Language: | English |
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Śląski Uniwersytet Medyczny w Katowicach
2025-05-01
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| Series: | Annales Academiae Medicae Silesiensis |
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| Online Access: | https://annales.sum.edu.pl/Modern-treatment-approaches-for-erectile-dysfunction-review,205195,0,2.html |
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| _version_ | 1849720799212077056 |
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| author | Kamil Nikel Michał Stojko Joanna Smolarczyk Magdalena Piegza |
| author_facet | Kamil Nikel Michał Stojko Joanna Smolarczyk Magdalena Piegza |
| author_sort | Kamil Nikel |
| collection | DOAJ |
| description | Erectile dysfunction (ED) is a significant public health issue that affects both patients’ quality of life and their intimate relationships. While phosphodiesterase type 5 inhibitors (PDE5-Is) are the standard first-line treatment, a substantial proportion of patients fail to achieve satisfactory results. Growing interest in alternative treatment approaches has led to the exploration of novel therapies, including botulinum neurotoxin (BoNT). BoNT increases penile tissue blood supply by relaxing corpora cavernosa smooth muscle by inhibiting the release of acetylcholine. In this review, BoNT as a new agent in the treatment of ED and comparison with the safety and efficacy of advanced techniques like endovascular therapy, stem cell therapy, platelet-rich plasma therapy, and low-intensity shockwave therapy is discussed. The mechanisms of action, clinical trial results, and possible limitations of these approaches are discussed. According to recent research, BoNT is a potential alternative for ED patients who are not responsive to traditional treatments. Additional studies, however, are required to establish optimal dosing regimens and determine the long-term benefits of these new therapeutic approaches. |
| format | Article |
| id | doaj-art-190ea8661e674142817da5aa02bdf2e9 |
| institution | DOAJ |
| issn | 1734-025X |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Śląski Uniwersytet Medyczny w Katowicach |
| record_format | Article |
| series | Annales Academiae Medicae Silesiensis |
| spelling | doaj-art-190ea8661e674142817da5aa02bdf2e92025-08-20T03:11:52ZengŚląski Uniwersytet Medyczny w KatowicachAnnales Academiae Medicae Silesiensis1734-025X2025-05-017915916710.18794/aams/205195Modern treatment approaches for erectile dysfunction – reviewKamil Nikel0https://orcid.org/0009-0007-9851-7129Michał Stojko1https://orcid.org/0009-0000-4960-3185Joanna Smolarczyk2https://orcid.org/0000-0003-4297-8974Magdalena Piegza3https://orcid.org/0000-0002-8009-7118Students’ Scientific Club, Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, PolandStudents’ Scientific Club, Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland Department of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, PolandDepartment of Psychiatry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland Erectile dysfunction (ED) is a significant public health issue that affects both patients’ quality of life and their intimate relationships. While phosphodiesterase type 5 inhibitors (PDE5-Is) are the standard first-line treatment, a substantial proportion of patients fail to achieve satisfactory results. Growing interest in alternative treatment approaches has led to the exploration of novel therapies, including botulinum neurotoxin (BoNT). BoNT increases penile tissue blood supply by relaxing corpora cavernosa smooth muscle by inhibiting the release of acetylcholine. In this review, BoNT as a new agent in the treatment of ED and comparison with the safety and efficacy of advanced techniques like endovascular therapy, stem cell therapy, platelet-rich plasma therapy, and low-intensity shockwave therapy is discussed. The mechanisms of action, clinical trial results, and possible limitations of these approaches are discussed. According to recent research, BoNT is a potential alternative for ED patients who are not responsive to traditional treatments. Additional studies, however, are required to establish optimal dosing regimens and determine the long-term benefits of these new therapeutic approaches.https://annales.sum.edu.pl/Modern-treatment-approaches-for-erectile-dysfunction-review,205195,0,2.htmlerectile dysfunctionmodern treatmentbotulinum toxinsexual health |
| spellingShingle | Kamil Nikel Michał Stojko Joanna Smolarczyk Magdalena Piegza Modern treatment approaches for erectile dysfunction – review Annales Academiae Medicae Silesiensis erectile dysfunction modern treatment botulinum toxin sexual health |
| title | Modern treatment approaches for erectile dysfunction – review |
| title_full | Modern treatment approaches for erectile dysfunction – review |
| title_fullStr | Modern treatment approaches for erectile dysfunction – review |
| title_full_unstemmed | Modern treatment approaches for erectile dysfunction – review |
| title_short | Modern treatment approaches for erectile dysfunction – review |
| title_sort | modern treatment approaches for erectile dysfunction review |
| topic | erectile dysfunction modern treatment botulinum toxin sexual health |
| url | https://annales.sum.edu.pl/Modern-treatment-approaches-for-erectile-dysfunction-review,205195,0,2.html |
| work_keys_str_mv | AT kamilnikel moderntreatmentapproachesforerectiledysfunctionreview AT michałstojko moderntreatmentapproachesforerectiledysfunctionreview AT joannasmolarczyk moderntreatmentapproachesforerectiledysfunctionreview AT magdalenapiegza moderntreatmentapproachesforerectiledysfunctionreview |