Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction

Reconstructing the Stem Leydig Cell Niche via the Testicular Extracellular Matrix for the Treatment of Testicular Leydig Cell Dysfunction

Abstract Therapies involving the use of stem Leydig cells (SLCs), as testicular mesenchymal stromal cells, have shown great promise in the treatment of Leydig cell (LC) dysfunction in aging males. However, the outcomes of these therapies are not satisfactory. In this study, it is demonstrated that t...

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Bibliographic Details
Main Authors: Ani Chi, Chao Yang, Jie Liu, Zhichen Zhai, Xuetao Shi
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
aging
extracellular matrix
Leydig cell
stem Leydig cell
Online Access:https://doi.org/10.1002/advs.202410808
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