Oligodendrocyte-Specific STAT5B Overexpression Ameliorates Myelin Impairment in Experimental Models of Parkinson’s Disease

Oligodendrocyte-Specific STAT5B Overexpression Ameliorates Myelin Impairment in Experimental Models of Parkinson’s Disease

<b>Background:</b> Parkinson’s disease (PD) involves progressive dopaminergic neuron degeneration and motor deficits. Oligodendrocyte dysfunction contributes to PD pathogenesis through impaired myelination. <b>Methods:</b> Single-nucleus RNA sequencing (snRNA-seq) of PD mice...

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Bibliographic Details
Main Authors: Yibo Li, Zhaowen Su, Jitong Zhai, Qing Liu, Hongfang Wang, Jiaxin Hao, Xiaofeng Tian, Jiamin Gao, Dandan Geng, Lei Wang
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Cells
Subjects:
Parkinson’s disease
oligodendrocyte
substantia nigra
single-nuclear RNA sequencing
myelin sheath
methylation
Online Access:https://www.mdpi.com/2073-4409/14/15/1145
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