The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans

The combination of metformin and high glucose increased longevity of Caenorhabditis elegans a DAF-16/FOXO-independent manner: cancer/diabetic model via C. elegans

IntroductionSedentary lifestyles and diets with high glycemic indexes are considered to be contributing factors to the development of obesity, type 2 diabetes in humans. Metformin, a biguanide medication commonly used to treat type 2 diabetes, has been observed to be associated with longevity; howev...

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Bibliographic Details
Main Authors: Şeyda Berk, Ali Cetin, Özgür Ülkü Özdemir, Ayşe Nur Pektaş, Nazan Yurtcu, Sevgi Durna Dastan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Endocrinology
Subjects:
aging
C. elegans
glucose
lifespan
lin-35
metformin
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1435098/full
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